Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways - PubMed (original) (raw)
Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways
L Coussens et al. Science. 1986.
Abstract
A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.
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