MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort - PubMed (original) (raw)

. 2023 Nov;68(11):4212-4220.

doi: 10.1007/s10620-023-08104-y. Epub 2023 Sep 8.

Joseph Akambase 1, Jhon Prieto 2, Domingo Balderramo 3, Javier Diaz Ferrer 4, Angelo Z Mattos 5, Marco Arrese 6, Enrique Carrera 7, Zwier M A Groothuismink 8, Jeffrey Oliveira 8, Andre Boonstra 8, Jose D Debes 9 10 11

Affiliations

MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort

Spencer Goble et al. Dig Dis Sci. 2023 Nov.

Abstract

Background: The rs641738 C > T single-nucleotide polymorphism of MBOAT7 has been associated with hepatocellular carcinoma (HCC) and nonalcoholic fatty liver disease (NAFLD). Latin Americans have high rates of HCC and NAFLD, but no assessment between MBOAT7 and HCC has been performed in this population.

Aims: We provide the first assessment of the impact of MBOAT7 on HCC risk in Latin Americans.

Methods: Patients were prospectively recruited into the ESCALON network, designed to collect samples from Latin American patients with HCC in 6 South American countries (Argentina, Ecuador, Brazil, Chile, Peru, and Colombia). A European cohort and the general Hispanic population of gnomAD database were included for comparison. Associations between HCC and MBOAT7 were evaluated using logistic regression.

Results: In total, 310 cases of HCC and 493 cases of cirrhosis without HCC were assessed. The MBOAT7 TT genotype was not predictive of HCC in Latin Americans (TT vs CC OR adjusted = 1.15, 95% CI 0.66-2.01, p = 0.610) or Europeans (TT vs CC OR adjusted = 1.20, 95% CI 0.59-2.43, p = 0.621). No significant association was noted on subgroup analysis for NAFLD, viral hepatitis, or alcohol-related liver disease. The TT genotype was increased in the NAFLD-cirrhosis cohort of Latin Americans compared to a non-cirrhotic NAFLD cohort (TT vs CC + CT OR = 2.75, 95% CI 1.10-6.87, p = 0.031).

Conclusion: The rs631738 C > T allele of MBOAT7 was not associated with increased risk of HCC in Latin Americans or Europeans. An increase in the risk of cirrhosis was noted with the TT genotype in Latin Americans with NAFLD.

Keywords: Hepatocellular carcinoma; Hispanic or Latino; Liver cirrhosis; Nonalcoholic fatty liver disease.

© 2023. The Author(s).

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Conflict of interest statement

The contributing authors have no financial, professional, personal, or other conflicts of interest to declare.

Figures

Fig. 1

Fig. 1

The genotype frequency distribution of the MBOAT7 rs641738 C > T single-nucleotide polymorphism in patients with hepatocellular carcinoma compared to patients with cirrhosis without hepatocellular carcinoma. Genotype frequency is stratified by geographic patient location in two separate cohorts, Europeans and Latin Americans. HCC hepatocellular carcinoma

Fig. 2

Fig. 2

The genotype frequency distribution of the MBOAT7 rs641738 C > T single-nucleotide polymorphism in patients with hepatocellular carcinoma. Frequencies are compared between patients of different current geographic location and descent with a European cohort, a Latin American cohort of European descent and a Latin American cohort of non-European descent

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