Possible association of platelet-derived growth factor (PDGF) with the appearance of reactive astrocytes following brain injury in situ - PubMed (original) (raw)
Possible association of platelet-derived growth factor (PDGF) with the appearance of reactive astrocytes following brain injury in situ
Y Takamiya et al. Brain Res. 1986.
Abstract
The association of platelet-derived growth factor (PDGF) with the appearance of reactive astrocytes following injury was investigated by using a specific antagonist of PDGF, Trapidil. The cerebral cortex of 4-week-old male rats was unilaterally injured with a 22-gauge needle. Immunohistochemical staining with antiserum to glial fibrillary acidic protein revealed that reactive astrocytes had increased in number around the wound by 2 days following the injury and had spread to the ipsilateral areas distant from the wound by 3 days. The appearance of reactive astrocytes in areas distant from the wound was dramatically suppressed by the administration of Trapidil. This finding indicates that PDGF might play a role in gliosis following injury.
Similar articles
- Evidence for "response to injury" hypothesis.
Ohnishi H, Yamaguchi K, Shimada S, Sato M, Funatc H, Katsuki Y, Dabasaki T, Suzuki Y, Saitoh Y, Kumagai A. Ohnishi H, et al. Life Sci. 1982 Dec 6;31(23):2595-602. doi: 10.1016/0024-3205(82)90734-2. Life Sci. 1982. PMID: 7154855 - Inhibitory effects of trapidil on PDGF signaling in balloon-injured rat carotid artery.
Deguchi J, Abe J, Makuuchi M, Takuwa Y. Deguchi J, et al. Life Sci. 1999;65(26):2791-9. doi: 10.1016/s0024-3205(99)00547-0. Life Sci. 1999. PMID: 10622268 - Antiproliferative effect of trapidil, a platelet-derived growth factor antagonist, on a glioma cell line in vitro.
Kuratsu J, Ushio Y. Kuratsu J, et al. J Neurosurg. 1990 Sep;73(3):436-40. doi: 10.3171/jns.1990.73.3.0436. J Neurosurg. 1990. PMID: 2384782 - The effect of trapidil on the reactive astrocytic proliferation following spinal cord trauma in rats: light and electron microscopic findings.
Göçer AI, Polat S, Ozel S, Tuna M, Kaya M, Cetinalp E, Haciyakupoglu S. Göçer AI, et al. Neurol Res. 1998 Jun;20(4):365-73. Neurol Res. 1998. PMID: 9618703 - Growth Factors and Astrocytes Metabolism: Possible Roles for Platelet Derived Growth Factor.
Cabezas R, Avila-Rodriguez M, Vega-Vela NE, Echeverria V, González J, Hidalgo OA, Santos AB, Aliev G, Barreto GE. Cabezas R, et al. Med Chem. 2016;12(3):204-10. doi: 10.2174/1573406411666151019120444. Med Chem. 2016. PMID: 26477707 Review.
Cited by
- Inhibition of reactive gliosis prevents neovascular growth in the mouse model of oxygen-induced retinopathy.
DeNiro M, Al-Mohanna FH, Al-Mohanna FA. DeNiro M, et al. PLoS One. 2011;6(7):e22244. doi: 10.1371/journal.pone.0022244. Epub 2011 Jul 14. PLoS One. 2011. PMID: 21779402 Free PMC article. Retracted. - Transplanting oligodendrocyte progenitors into the adult CNS.
Franklin RJ, Blakemore WF. Franklin RJ, et al. J Anat. 1997 Jan;190 ( Pt 1)(Pt 1):23-33. doi: 10.1046/j.1469-7580.1997.19010023.x. J Anat. 1997. PMID: 9034879 Free PMC article. Review. - Chronological study of peripheral benzodiazepine binding sites in the rat brain stab wounds using [3H] PK-11195 as a marker for gliosis.
Miyazawa N, Diksic M, Yamamoto Y. Miyazawa N, et al. Acta Neurochir (Wien). 1995;137(3-4):207-16. doi: 10.1007/BF02187195. Acta Neurochir (Wien). 1995. PMID: 8789663
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources