Malignant conversion and metastasis of mouse skin tumors: a comparison of SENCAR and CD-1 mice - PubMed (original) (raw)
Comparative Study
Malignant conversion and metastasis of mouse skin tumors: a comparison of SENCAR and CD-1 mice
H Hennings et al. Environ Health Perspect. 1986 Sep.
Abstract
The progression of papillomas to squamous cell carcinomas (malignant conversion) was studied in the skin of SENCAR and Charles River CD-1 mice, using a three-stage treatment protocol. After initiation with 7,12-dimethylbenz(a)anthracene (DMBA) (stage 1) and limited promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) (stage II), papilloma-bearing mice were treated (stage III) with either tumor initiators, such as urethane, N-methyl-N'nitro-N-nitrosoguanidine (MNNG) or 4-nitroquinoline-n-oxide (R-NQO), the promoter TPA, or solvent (acetone). Similar final carcinoma yields were found in the mice treated in stage III with TPA or acetone, although carcinomas developed earlier in the TPA-treated mice. In contrast, treatment with tumor initiators in stage III increased both the rate of appearance and the final yield of carcinomas. Similar results were obtained in both SENCAR and CD-1 mice. A papilloma stage appears to be necessary for carcinoma development since elimination of TPA treatment in stage II greatly reduced the incidence of both papillomas and carcinomas in both stocks of mice. The heterogeneity of papillomas with regard to progression to carcinomas is demonstrated by the low rate of conversion of TPA-dependent papillomas and the high rate of conversion of persistent papillomas in CD-1 mice. The carcinomas that develop using the three-stage regimen vary in metastatic potential. In CD-1 mice, the frequency of metastases to lymph nodes were similar in groups treated in stage III with MNNG, urethane, 4-NQO, TPA, or acetone, but treatment with urethane substantially increased metastases to the lung.(ABSTRACT TRUNCATED AT 250 WORDS)
Similar articles
- New strains of inbred SENCAR mice with increased susceptibility to induction of papillomas and squamous cell carcinomas in skin.
Hennings H, Lowry DT, Yuspa SH, Mock B, Potter M. Hennings H, et al. Mol Carcinog. 1997 Sep;20(1):143-50. doi: 10.1002/(sici)1098-2744(199709)20:1<143::aid-mc16>3.0.co;2-1. Mol Carcinog. 1997. PMID: 9328445 - Malignant conversion, the first stage in progression, is distinct from phorbol ester promotion in mouse skin.
Hennings H. Hennings H. Basic Life Sci. 1991;57:31-9; discussion 39-42. doi: 10.1007/978-1-4684-5994-4_4. Basic Life Sci. 1991. PMID: 1814291 - Sensitivity of subpopulations of mouse skin papillomas to malignant conversion by urethane or 4-nitroquinoline N-oxide.
Hennings H, Shores R, Balaschak M, Yuspa SH. Hennings H, et al. Cancer Res. 1990 Feb 1;50(3):653-7. Cancer Res. 1990. PMID: 2105160 - SENCAR mouse skin tumorigenesis model versus other strains and stocks of mice.
Slaga TJ. Slaga TJ. Environ Health Perspect. 1986 Sep;68:27-32. doi: 10.1289/ehp.866827. Environ Health Perspect. 1986. PMID: 3096709 Free PMC article. Review. - Multistage carcinogenesis in mouse skin.
DiGiovanni J. DiGiovanni J. Pharmacol Ther. 1992;54(1):63-128. doi: 10.1016/0163-7258(92)90051-z. Pharmacol Ther. 1992. PMID: 1528955 Review.
Cited by
- Cutaneous papilloma and squamous cell carcinoma therapy utilizing nanosecond pulsed electric fields (nsPEF).
Yin D, Yang WG, Weissberg J, Goff CB, Chen W, Kuwayama Y, Leiter A, Xing H, Meixel A, Gaut D, Kirkbir F, Sawcer D, Vernier PT, Said JW, Gundersen MA, Koeffler HP. Yin D, et al. PLoS One. 2012;7(8):e43891. doi: 10.1371/journal.pone.0043891. Epub 2012 Aug 28. PLoS One. 2012. PMID: 22937117 Free PMC article. - Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.
Glick AB, Kulkarni AB, Tennenbaum T, Hennings H, Flanders KC, O'Reilly M, Sporn MB, Karlsson S, Yuspa SH. Glick AB, et al. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6076-80. doi: 10.1073/pnas.90.13.6076. Proc Natl Acad Sci U S A. 1993. PMID: 7687059 Free PMC article. - Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications.
Abel EL, Angel JM, Kiguchi K, DiGiovanni J. Abel EL, et al. Nat Protoc. 2009;4(9):1350-62. doi: 10.1038/nprot.2009.120. Epub 2009 Aug 27. Nat Protoc. 2009. PMID: 19713956 Free PMC article. - Chemically induced skin carcinogenesis: Updates in experimental models (Review).
Neagu M, Caruntu C, Constantin C, Boda D, Zurac S, Spandidos DA, Tsatsakis AM. Neagu M, et al. Oncol Rep. 2016 May;35(5):2516-28. doi: 10.3892/or.2016.4683. Epub 2016 Mar 17. Oncol Rep. 2016. PMID: 26986013 Free PMC article. Review.
References
- Cancer Res. 1972 Jul;32(7):1562-8 - PubMed
- Cancer Res. 1976 Apr;36(4):1422-7 - PubMed
- Br J Cancer. 1953 Sep;7(3):342-51 - PubMed
- Environ Health Perspect. 1983 Apr;50:3-14 - PubMed
- Cancer Res. 1984 Sep;44(9):3779-82 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical