Differential growth properties of metastatic large-cell lymphoma cells in target organ-conditioned medium - PubMed (original) (raw)
Comparative Study
Differential growth properties of metastatic large-cell lymphoma cells in target organ-conditioned medium
G L Nicolson. Exp Cell Res. 1987 Feb.
Abstract
Metastatic variant sublines of the murine RAW117-P large cell lymphoma have been sequentially selected in vivo for enhanced liver (RAW117-H10) or lung (RAW117-L17) colonization. Such cell sublines were tested for their survival and growth in vitro in medium conditioned by soluble factors released from mouse kidney, brain, liver, or lung tissues. Liver-colonizing H10 and L17 sublines were growth-stimulated by target liver tissue-derived factors at concentrations that inhibited the growth of the parental cells. Lung-colonizing L17 as well as liver-colonizing H10 cells were stimulated by lung tissue factors at concentrations that growth-inhibited the parental cells. In contrast, there was no significant growth stimulation by factors from kidney or brain tissues. In general, the metastatic patterns of RAW117 cells correlated with their abilities to be stimulated by medium from target organ tissues, but other factors, such as organ-specific adhesion mechanisms [10-12], must also be involved in the specificity of blood-borne metastatic organ colonization.
Similar articles
- Separable growth and migration factors for large-cell lymphoma cells secreted by microvascular endothelial cells derived from target organs for metastasis.
Hamada J, Cavanaugh PG, Lotan O, Nicolson GL. Hamada J, et al. Br J Cancer. 1992 Aug;66(2):349-54. doi: 10.1038/bjc.1992.269. Br J Cancer. 1992. PMID: 1503910 Free PMC article. - Adhesive, invasive, and growth properties of selected metastatic variants of a murine large-cell lymphoma.
Nicolson GL, Belloni PN, Tressler RJ, Dulski K, Inoue T, Cavanaugh PG. Nicolson GL, et al. Invasion Metastasis. 1989;9(2):102-16. Invasion Metastasis. 1989. PMID: 2708004 - Involvement of cell-cell adhesion molecules in liver colonization by metastatic murine lymphoma/lymphosarcoma variants.
McGuire EJ, Mascali JJ, Grady SR, Nicolson GL. McGuire EJ, et al. Clin Exp Metastasis. 1984 Jul-Sep;2(3):213-22. doi: 10.1007/BF00132928. Clin Exp Metastasis. 1984. PMID: 6549550 - Nonmetastatic tumor cells acquire metastatic properties following somatic hybridization with normal cells.
De Baetselier P, Roos E, Brys L, Remels L, Gobert M, Dekegel D, Segal S, Feldman M. De Baetselier P, et al. Cancer Metastasis Rev. 1984;3(1):5-24. doi: 10.1007/BF00047690. Cancer Metastasis Rev. 1984. PMID: 6370419 Review. - Specificity of arrest, survival, and growth of selected metastatic variant cell lines.
Nicolson GL, Brunson KW, Fidler IJ. Nicolson GL, et al. Cancer Res. 1978 Nov;38(11 Pt 2):4105-11. Cancer Res. 1978. PMID: 359132 Review.
Cited by
- Differential motility stimulation but not growth stimulation or adhesion of metastatic human colorectal carcinoma cells by target organ-derived liver sinusoidal endothelial cells.
Sawada H, Wakabayashi H, Nawa A, Mora E, Cavanaugh PG, Nicolson GL. Sawada H, et al. Clin Exp Metastasis. 1996 May;14(3):308-13. doi: 10.1007/BF00053904. Clin Exp Metastasis. 1996. PMID: 8674285 - Establishment of a hepatocyte cell line producing growth-promoting factors for liver-colonizing tumor cells.
Yamori T, Shimada K, Kanda H, Nishizuru Y, Komi A, Yamazaki K, Asanoma K, Ogawa M, Nomura K, Nemoto N, Kumada K, Tsuruo T. Yamori T, et al. Jpn J Cancer Res. 1996 Feb;87(2):146-52. doi: 10.1111/j.1349-7006.1996.tb03152.x. Jpn J Cancer Res. 1996. PMID: 8609063 Free PMC article. - The role of the spleen in the organ-specific metastasis of murine BW 5147 T lymphomas.
Schmidt C, Verschueren H, Toussaint-Demylle D, van den Berg T, Kraal G, De Baetselier P. Schmidt C, et al. Clin Exp Metastasis. 1994 Mar;12(2):164-74. doi: 10.1007/BF01753983. Clin Exp Metastasis. 1994. PMID: 8306530 - Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis.
Nicolson GL. Nicolson GL. Cancer Metastasis Rev. 1993 Sep;12(3-4):325-43. doi: 10.1007/BF00665961. Cancer Metastasis Rev. 1993. PMID: 8281616 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical