Instability of large direct repeats in retrovirus vectors - PubMed (original) (raw)

Instability of large direct repeats in retrovirus vectors

B W Rhode et al. J Virol. 1987 Mar.

Abstract

Retrovirus vectors were constructed with large (0.85- to 1.3-kilobase-pair) direct repeats in their genomes. Deletions involving the direct repeats occurred at a high frequency. Deletions occurred both when the direct repeats were in tandem and when they were separated by additional sequences. These deletions occurred during virus replication.

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