A 5'-flanking region of the chicken acetylcholine receptor alpha-subunit gene confers tissue specificity and developmental control of expression in transfected cells - PubMed (original) (raw)

A 5'-flanking region of the chicken acetylcholine receptor alpha-subunit gene confers tissue specificity and developmental control of expression in transfected cells

A Klarsfeld et al. Mol Cell Biol. 1987 Feb.

Abstract

The 5' end and promoter region of the alpha-subunit gene of chicken muscle acetylcholine receptor was mapped and sequenced. It includes a TATA and a CAAT box and a potential Sp1-binding site. When inserted in front of the chloramphenicol acetyltransferase gene, this promoter (including 850 base pairs of upstream sequence) directed high transient chloramphenicol acetyltransferase expression in transfected mouse C2.7 myotubes but not in C2.7 myoblasts or nonmyogenic 3T6 cells.

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References

1. Nature. 1976 Nov 25;264(5584):368-9 - PubMed
1. Annu Rev Cell Biol. 1985;1:317-51 - PubMed
1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
1. Physiol Rev. 1979 Jan;59(1):165-227 - PubMed
1. Eur J Biochem. 1980 Jun;107(2):303-14 - PubMed

A 5'-flanking region of the chicken acetylcholine receptor alpha-subunit gene confers tissue specificity and developmental control of expression in transfected cells - PubMed (original) (raw)