Host-parasite relationship of Leishmania mexicana mexicana and Lutzomyia abonnenci (Diptera: Psychodidae) - PubMed (original) (raw)
Host-parasite relationship of Leishmania mexicana mexicana and Lutzomyia abonnenci (Diptera: Psychodidae)
L L Walters et al. Am J Trop Med Hyg. 1987 Mar.
Abstract
The life cycle of Leishmania mexicana mexicana in the gut of the sand fly, Lutzomyia abonnenci, was studied by light and electron microscopy. Development was suprapylarian with initial establishment of parasites in the bloodmeal (posterior midgut), and anterior migration of parasites to the cardia/stomodeal valve region beginning at 2.5 days post-infection. Flagellates were first observed in the esophagus at 3.5 days, in the posterior armature region of the pharynx at 5 days, and in the anterior pharynx at 7 days; but they were not detected in the cibarium or proboscis. Infection of the pylorus region of the hindgut and of the Malpighian tubules was also commonly observed. Three different morphological forms of L. m. mexicana developed in the gut: nectomonad promastigotes, short promastigotes, and paramastigotes. Nectomonads occurred primarily in the abdominal midgut after bloodmeal digestion, where they were oriented in longitudinal masses in the lumen, or interdigitated with epithelial microvilli via the flagellum. Short promastigotes found in the cardia/stomodeal valve region are described for the first time. These forms were smaller than nectomonads, showed an amplification of the kinetoplast, apposition of kinetoplast and nucleus, and were embedded in a gel-like matrix. To maintain position in the cardia, parasites commonly inserted the flagellum deep into microvilli or cytoplasm of the epithelium; adherence to the cuticular intima of the stomodeal valve was by flagellar modification and formation of hemidesmosome plaques. Paramastigotes occurred in the esophagus, were sometimes degenerated in appearance, and were attached via flagellar hemidesmosomes. Paramastigotes observed in the lumen of the pharynx were commonly degenerated and were not attached to the intima. L. m. mexicana was able to colonize the various gut habitats of Lu. abonnenci by a number of adaptations; this sand fly appears to be a suitable biological host for the parasite.
Similar articles
- Ultrastructural development of Leishmania chagasi in its vector, Lutzomyia longipalpis (Diptera: Psychodidae).
Walters LL, Modi GB, Chaplin GL, Tesh RB. Walters LL, et al. Am J Trop Med Hyg. 1989 Sep;41(3):295-317. Am J Trop Med Hyg. 1989. PMID: 2802019 - Life cycle of Leishmania major (Kinetoplastida: Trypanosomatidae) in the neotropical sand fly Lutzomyia longipalpis (Diptera: Psychodidae).
Walters LL, Irons KP, Chaplin G, Tesh RB. Walters LL, et al. J Med Entomol. 1993 Jul;30(4):699-718. doi: 10.1093/jmedent/30.4.699. J Med Entomol. 1993. PMID: 8360894 - Leishmania differentiation in natural and unnatural sand fly hosts.
Walters LL. Walters LL. J Eukaryot Microbiol. 1993 Mar-Apr;40(2):196-206. doi: 10.1111/j.1550-7408.1993.tb04904.x. J Eukaryot Microbiol. 1993. PMID: 8461893 Review. - New insights into the developmental biology and transmission mechanisms of Leishmania.
Bates PA, Rogers ME. Bates PA, et al. Curr Mol Med. 2004 Sep;4(6):601-9. doi: 10.2174/1566524043360285. Curr Mol Med. 2004. PMID: 15357211 Review.
Cited by
- Porcisia transmission by prediuresis of sand flies.
Sadlova J, Bacikova D, Becvar T, Vojtkova B, England M, Shaw J, Volf P. Sadlova J, et al. Front Cell Infect Microbiol. 2022 Aug 10;12:981071. doi: 10.3389/fcimb.2022.981071. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36034718 Free PMC article. - The role of leishmania proteophosphoglycans in sand fly transmission and infection of the Mammalian host.
Rogers ME. Rogers ME. Front Microbiol. 2012 Jun 28;3:223. doi: 10.3389/fmicb.2012.00223. eCollection 2012. Front Microbiol. 2012. PMID: 22754550 Free PMC article. - Stage-specific adhesion of Leishmania promastigotes to sand fly midguts assessed using an improved comparative binding assay.
Wilson R, Bates MD, Dostalova A, Jecna L, Dillon RJ, Volf P, Bates PA. Wilson R, et al. PLoS Negl Trop Dis. 2010 Sep 7;4(9):e816. doi: 10.1371/journal.pntd.0000816. PLoS Negl Trop Dis. 2010. PMID: 20838647 Free PMC article. - Structural changes of the paraflagellar rod during flagellar beating in Trypanosoma cruzi.
Rocha GM, Teixeira DE, Miranda K, Weissmüller G, Bisch PM, de Souza W. Rocha GM, et al. PLoS One. 2010 Jun 30;5(6):e11407. doi: 10.1371/journal.pone.0011407. PLoS One. 2010. PMID: 20613980 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Miscellaneous