Interaction of antidepressants with antiparkinsonian agents in rats - PubMed (original) (raw)
. 1985 Nov-Dec;37(6):865-74.
- PMID: 3832020
Interaction of antidepressants with antiparkinsonian agents in rats
I Zebrowska-Lupina et al. Pol J Pharmacol Pharm. 1985 Nov-Dec.
Abstract
The influence of antidepressants: nomifensine, imipramine, amitriptyline and trazodone on the effect of antiparkinsonian agents: trihexyphenidil and L-DOPA + carbidopa mixture (sinemet) in the model of haloperidol catalepsy was investigated in rats. In some experiments deprenyl, a selective MAO-B inhibitor, was used. It was found that antidepressant drugs in doses not influencing haloperidol catalepsy enhanced significantly the anticataleptic effect of trihexyphenidil and L-DOPA + carbidopa. The most effective in the interaction with both antiparkinsonian agents was nomifensine. Imipramine and trazodone potentiated anticataleptic effect of L-DOPA + carbidopa more strongly than those of trihexyphenidil. The most potent anticataleptic effect was observed after combined treatment of rats with deprenyl and L-DOPA + carbidopa.
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