Repeat sequence families derived from mammalian tRNA genes - PubMed (original) (raw)
Comparative Study
Repeat sequence families derived from mammalian tRNA genes
G R Daniels et al. Nature. 1985.
Abstract
Short interspersed repetitive DNA sequences (SINEs) are the major component of dispersed repetitive DNA in all mammalian genomes. Most SINEs contain an intragenic RNA polymerase III promoter that initiates transcription at the 5' end of the repeated DNA sequence and which has been proposed to facilitate the transposition and amplification of these sequences by an RNA-intermediate mechanism. We have discovered several SINE families in the prosimian Galago crassicaudatus which have promoter regions similar to transfer RNA genes. To determine the relationship between Galago SINEs and mammalian tRNA genes, we have compared their sequences. Here, we demonstrate that the Galago monomer and type II SINE families are 68 and 62% homologous, respectively, with a human methionine tRNA gene. We have extended our analysis to include the rat identifier and mouse B2 families and show that their sequences are closely related to alanine and serine tRNA genes, respectively. Our observations suggest that many mammalian SINE families are amplified tRNA pseudogenes.
Similar articles
- Characterization of a third major SINE family of repetitive sequences in the galago genome.
Daniels GR, Deininger PL. Daniels GR, et al. Nucleic Acids Res. 1991 Apr 11;19(7):1649-56. doi: 10.1093/nar/19.7.1649. Nucleic Acids Res. 1991. PMID: 1840654 Free PMC article. - SINEs.
Okada N. Okada N. Curr Opin Genet Dev. 1991 Dec;1(4):498-504. doi: 10.1016/s0959-437x(05)80198-4. Curr Opin Genet Dev. 1991. PMID: 1668310 Review. - PCR-based approach to SINE isolation: simple and complex SINEs.
Borodulina OR, Kramerov DA. Borodulina OR, et al. Gene. 2005 Apr 11;349:197-205. doi: 10.1016/j.gene.2004.12.035. Gene. 2005. PMID: 15777739 - The beta globin gene cluster of the prosimian primate Galago crassicaudatus: nucleotide sequence determination of the 41-kb cluster and comparative sequence analyses.
Tagle DA, Stanhope MJ, Siemieniak DR, Benson P, Goodman M, Slightom JL. Tagle DA, et al. Genomics. 1992 Jul;13(3):741-60. doi: 10.1016/0888-7543(92)90150-q. Genomics. 1992. PMID: 1639402 - The mammalian genome shaping activity of reverse transcriptase.
Nouvel P. Nouvel P. Genetica. 1994;93(1-3):191-201. doi: 10.1007/BF01435251. Genetica. 1994. PMID: 7529206 Review.
Cited by
- A new rice repetitive DNA shows sequence homology to both 5S RNA and tRNA.
Wu TY, Wu R. Wu TY, et al. Nucleic Acids Res. 1987 Aug 11;15(15):5913-23. doi: 10.1093/nar/15.15.5913. Nucleic Acids Res. 1987. PMID: 3627973 Free PMC article. - Murine Gammaherpesvirus 68 ORF45 Stimulates B2 Retrotransposon and Pre-tRNA Activation in a Manner Dependent on Mitogen-Activated Protein Kinase (MAPK) Signaling.
Lari A, Glaunsinger BA. Lari A, et al. Microbiol Spectr. 2023 Feb 8;11(2):e0017223. doi: 10.1128/spectrum.00172-23. Online ahead of print. Microbiol Spectr. 2023. PMID: 36752632 Free PMC article. - tRNAscan-SE: Searching for tRNA Genes in Genomic Sequences.
Chan PP, Lowe TM. Chan PP, et al. Methods Mol Biol. 2019;1962:1-14. doi: 10.1007/978-1-4939-9173-0_1. Methods Mol Biol. 2019. PMID: 31020551 Free PMC article. - Navigating the brain and aging: exploring the impact of transposable elements from health to disease.
Le Breton A, Bettencourt MP, Gendrel AV. Le Breton A, et al. Front Cell Dev Biol. 2024 Feb 27;12:1357576. doi: 10.3389/fcell.2024.1357576. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 38476259 Free PMC article. Review. - SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation.
Varshney D, Vavrova-Anderson J, Oler AJ, Cowling VH, Cairns BR, White RJ. Varshney D, et al. Nat Commun. 2015 Mar 23;6:6569. doi: 10.1038/ncomms7569. Nat Commun. 2015. PMID: 25798578 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources