Macrophage recognition of cells undergoing programmed cell death (apoptosis) - PubMed (original) (raw)
- PMID: 3876985
- PMCID: PMC1453689
Macrophage recognition of cells undergoing programmed cell death (apoptosis)
E Duvall et al. Immunology. 1985 Oct.
Abstract
As a model for the recognition of effete cells by their viable neighbours. BALB/c mouse thymocytes were coincubated with isologous peritoneal macrophages. The macrophages bound preferentially to thymocytes undergoing apoptosis, a mode of death induced in these cells by treatment with the glucocorticoid hormone methyl-prednisolone. Binding occurred in the absence of serum and was inhibited by N,N'-diacetyl chitobiose, N-acetyl glucosamine and, to a lesser extent, by N-acetyl galactosamine and D-galactose. L-fucose, D-mannose and N-acetyl neuraminic acid had no effect. The results suggest the presence of lectin-like molecules on the surface of the macrophage that recognize changes in the cell-surface carbohydrate of the apoptotic cell. The pattern of inhibition of binding by monosaccharides differs from that of previously described endogenous mammalian lectins.
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References
- Proc Natl Acad Sci U S A. 1966 Oct;56(4):1158-63 - PubMed
- Am J Pathol. 1984 Jun;115(3):426-36 - PubMed
- J Immunol. 1972 Apr;108(4):1092-7 - PubMed
- J Immunol. 1972 Jun;108(6):1609-14 - PubMed
- J Pathol. 1973 Oct;111(2):85-94 - PubMed
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