Spatially regulated expression of homeotic genes in Drosophila - PubMed (original) (raw)

Review

Spatially regulated expression of homeotic genes in Drosophila

K Harding et al. Science. 1985.

Abstract

The sites of transcript accumulation for six different homeotic loci of the Antennapedia and bithorax gene complexes (ANT-C and BX-C) were identified within embryo tissue sections by in situ hybridization. These six loci belong to the Antennapedia class of the homeo box gene family. Transcripts encoded by each locus are detected primarily in discrete, nonoverlapping regions of the embryonic central nervous system (CNS). The regions of the CNS that contain transcripts encoded by each of these loci correspond to the embryonic segments that are disrupted in mutants for these genes. The maintenance of spatially restricted expression of each ANT-C and BX-C locus could involve hierarchical, cross-regulatory interactions that are mediated by the homeo box protein domains encoded by these genes.

PubMed Disclaimer

Similar articles

• Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus in Drosophila.
  Wedeen C, Harding K, Levine M. Wedeen C, et al. Cell. 1986 Mar 14;44(5):739-48. doi: 10.1016/0092-8674(86)90840-8. Cell. 1986. PMID: 3081265
• Homeo box genes of the Antennapedia and bithorax complexes of Drosophila.
  Regulski M, Harding K, Kostriken R, Karch F, Levine M, McGinnis W. Regulski M, et al. Cell. 1985 Nov;43(1):71-80. doi: 10.1016/0092-8674(85)90013-3. Cell. 1985. PMID: 2416463
• Gap genes define the limits of antennapedia and bithorax gene expression during early development in Drosophila.
  Harding K, Levine M. Harding K, et al. EMBO J. 1988 Jan;7(1):205-14. doi: 10.1002/j.1460-2075.1988.tb02801.x. EMBO J. 1988. PMID: 2896123 Free PMC article.
• [Homeotic genes].
  Lepesant JA. Lepesant JA. Reprod Nutr Dev. 1990;Suppl 1:9s-26s. Reprod Nutr Dev. 1990. PMID: 1976313 Review. French.
• The bithorax complex of Drosophila an exceptional Hox cluster.
  Maeda RK, Karch F. Maeda RK, et al. Curr Top Dev Biol. 2009;88:1-33. doi: 10.1016/S0070-2153(09)88001-0. Curr Top Dev Biol. 2009. PMID: 19651300 Review.

Cited by

• Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos.
  Rekaik H, Lopez-Delisle L, Hintermann A, Mascrez B, Bochaton C, Mayran A, Duboule D. Rekaik H, et al. Nat Genet. 2023 Jul;55(7):1164-1175. doi: 10.1038/s41588-023-01426-7. Epub 2023 Jun 15. Nat Genet. 2023. PMID: 37322110 Free PMC article.
• Echiuran Hox genes provide new insights into the correspondence between Hox subcluster organization and collinearity pattern.
  Wei M, Qin Z, Kong D, Liu D, Zheng Q, Bai S, Zhang Z, Ma Y. Wei M, et al. Proc Biol Sci. 2022 Sep 14;289(1982):20220705. doi: 10.1098/rspb.2022.0705. Epub 2022 Sep 7. Proc Biol Sci. 2022. PMID: 36264643 Free PMC article.
• HOX genes in stem cells: Maintaining cellular identity and regulation of differentiation.
  Steens J, Klein D. Steens J, et al. Front Cell Dev Biol. 2022 Sep 13;10:1002909. doi: 10.3389/fcell.2022.1002909. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36176275 Free PMC article. Review.
• Evolution of stickleback spines through independent cis-regulatory changes at HOXDB.
  Wucherpfennig JI, Howes TR, Au JN, Au EH, Roberts Kingman GA, Brady SD, Herbert AL, Reimchen TE, Bell MA, Lowe CB, Dalziel AC, Kingsley DM. Wucherpfennig JI, et al. Nat Ecol Evol. 2022 Oct;6(10):1537-1552. doi: 10.1038/s41559-022-01855-3. Epub 2022 Sep 1. Nat Ecol Evol. 2022. PMID: 36050398 Free PMC article.
• CRISPR/Cas9-Mediated Mutagenesis of Abdominal-A and Ultrabithorax in the Asian Corn Borer, Ostrinia furnacalis.
  Bi H, Merchant A, Gu J, Li X, Zhou X, Zhang Q. Bi H, et al. Insects. 2022 Apr 13;13(4):384. doi: 10.3390/insects13040384. Insects. 2022. PMID: 35447826 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Atypon

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • FlyBase