DNA synthesis and cell division in the adult primate brain - PubMed (original) (raw)
Review
DNA synthesis and cell division in the adult primate brain
P Rakic. Ann N Y Acad Sci. 1985.
Abstract
Autoradiographic analysis of juvenile and adult monkeys that received single or multiple injection of the specific DNA precursor, [3H]thymidine, demonstrates slight turnover of glial cells, but failed to provide any evidence of either neuronal addition or replacement. Therefore, while the brains of nonmammalian vertebrates and possibly some nonprimate mammals may display variable degrees of postembryonic neurogenesis, all neurons of the primate central nervous system are generated during restricted developmental periods, mostly before birth and not after infancy. It is not surprising that a stable population of neurons in mature primates, including man, may be essential for the retention of memory and learned behavior.
Similar articles
- Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey.
Eckenhoff MF, Rakic P. Eckenhoff MF, et al. J Neurosci. 1988 Aug;8(8):2729-47. doi: 10.1523/JNEUROSCI.08-08-02729.1988. J Neurosci. 1988. PMID: 3411351 Free PMC article. - Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat.
Cameron HA, Woolley CS, McEwen BS, Gould E. Cameron HA, et al. Neuroscience. 1993 Sep;56(2):337-44. doi: 10.1016/0306-4522(93)90335-d. Neuroscience. 1993. PMID: 8247264 - Limits of neurogenesis in primates.
Rakic P. Rakic P. Science. 1985 Mar 1;227(4690):1054-6. doi: 10.1126/science.3975601. Science. 1985. PMID: 3975601 - Formation and turnover of neurons in young and senescent animals: an electronmicroscopic and morphometric analysis.
Kaplan MS. Kaplan MS. Ann N Y Acad Sci. 1985;457:173-92. doi: 10.1111/j.1749-6632.1985.tb20805.x. Ann N Y Acad Sci. 1985. PMID: 3913362 Review. No abstract available. - The surface-contact glia.
Hajós F, Bascó E. Hajós F, et al. Adv Anat Embryol Cell Biol. 1984;84:1-79. doi: 10.1007/978-3-642-69623-7. Adv Anat Embryol Cell Biol. 1984. PMID: 6377846 Review. No abstract available.
Cited by
- Quantum biology in low level light therapy: death of a dogma.
Sommer AP, Schemmer P, Pavláth AE, Försterling HD, Mester ÁR, Trelles MA. Sommer AP, et al. Ann Transl Med. 2020 Apr;8(7):440. doi: 10.21037/atm.2020.03.159. Ann Transl Med. 2020. PMID: 32395484 Free PMC article. - Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective.
Coller HA. Coller HA. Compr Physiol. 2019 Dec 18;10(1):317-344. doi: 10.1002/cphy.c190014. Compr Physiol. 2019. PMID: 31853969 Free PMC article. Review. - HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
Mattis VB, Tom C, Akimov S, Saeedian J, Østergaard ME, Southwell AL, Doty CN, Ornelas L, Sahabian A, Lenaeus L, Mandefro B, Sareen D, Arjomand J, Hayden MR, Ross CA, Svendsen CN. Mattis VB, et al. Hum Mol Genet. 2015 Jun 1;24(11):3257-71. doi: 10.1093/hmg/ddv080. Epub 2015 Mar 3. Hum Mol Genet. 2015. PMID: 25740845 Free PMC article. - CCK-immunoreactive terminals form different types of synapses in the rat and monkey hippocampus.
Leranth C, Frotscher M, Rakic P. Leranth C, et al. Histochemistry. 1988;88(3-6):343-52. doi: 10.1007/BF00570293. Histochemistry. 1988. PMID: 3366638 - Role of SOX family of transcription factors in central nervous system tumors.
de la Rocha AM, Sampron N, Alonso MM, Matheu A. de la Rocha AM, et al. Am J Cancer Res. 2014 Jul 16;4(4):312-24. eCollection 2014. Am J Cancer Res. 2014. PMID: 25057435 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical