Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein - PubMed (original) (raw)
Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein
A M Schultz et al. Science. 1985.
Abstract
The transforming protein of Rous sarcoma virus, p60src, was shown to be acylated at its amino terminus with the long-chain fatty acid myristic acid by isolation of a tryptic peptide with the following structure: myristylglycylserylseryllysine. The occurrence of this unusual posttranslational modification in the cyclic adenosine monophosphate-dependent protein kinase and in several transforming protein kinases of mammalian retroviruses suggests that myristylation of the amino terminal glycyl residue may be critical for the function of certain proteins related to cell transformation and growth control.
Similar articles
- An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins.
Pellman D, Garber EA, Cross FR, Hanafusa H. Pellman D, et al. Nature. 1985 Mar 28-Apr 3;314(6009):374-7. doi: 10.1038/314374a0. Nature. 1985. PMID: 3920530 - Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog.
Buss JE, Sefton BM. Buss JE, et al. J Virol. 1985 Jan;53(1):7-12. doi: 10.1128/JVI.53.1.7-12.1985. J Virol. 1985. PMID: 2981363 Free PMC article. - Processing of p60v-src to its myristylated membrane-bound form.
Garber EA, Cross FR, Hanafusa H. Garber EA, et al. Mol Cell Biol. 1985 Oct;5(10):2781-8. doi: 10.1128/mcb.5.10.2781-2788.1985. Mol Cell Biol. 1985. PMID: 3016513 Free PMC article. - Transformation by p60src with altered N-terminal sequences.
Hanafusa H, Garber EA, Hanafusa T. Hanafusa H, et al. Princess Takamatsu Symp. 1986;17:233-40. Princess Takamatsu Symp. 1986. PMID: 2843496 Review. - Activation of the abl oncogene in murine and human leukemias.
Konopka JB, Witte ON. Konopka JB, et al. Biochim Biophys Acta. 1985 Nov 12;823(1):1-17. doi: 10.1016/0304-419x(85)90012-5. Biochim Biophys Acta. 1985. PMID: 2996602 Review. No abstract available.
Cited by
- Across the Hall from Pioneers.
Rein A. Rein A. Viruses. 2021 Mar 16;13(3):491. doi: 10.3390/v13030491. Viruses. 2021. PMID: 33809689 Free PMC article. - DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes.
Tanaka A, Gibbs CP, Arthur RR, Anderson SK, Kung HJ, Fujita DJ. Tanaka A, et al. Mol Cell Biol. 1987 May;7(5):1978-83. doi: 10.1128/mcb.7.5.1978-1983.1987. Mol Cell Biol. 1987. PMID: 3299057 Free PMC article. - The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant.
Kaplan JM, Mardon G, Bishop JM, Varmus HE. Kaplan JM, et al. Mol Cell Biol. 1988 Jun;8(6):2435-41. doi: 10.1128/mcb.8.6.2435-2441.1988. Mol Cell Biol. 1988. PMID: 2841581 Free PMC article. - Effect of a membrane-targeted sphingosine kinase 1 on cell proliferation and survival.
Safadi-Chamberlain F, Wang LP, Payne SG, Lim CU, Stratford S, Chavez JA, Fox MH, Spiegel S, Summers SA. Safadi-Chamberlain F, et al. Biochem J. 2005 Jun 15;388(Pt 3):827-34. doi: 10.1042/BJ20041726. Biochem J. 2005. PMID: 15693752 Free PMC article. - Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis.
Bagrodia S, Taylor SJ, Shalloway D. Bagrodia S, et al. Mol Cell Biol. 1993 Mar;13(3):1464-70. doi: 10.1128/mcb.13.3.1464-1470.1993. Mol Cell Biol. 1993. PMID: 7680096 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources