Schistosoma mansoni: eicosanoid production by cercariae - PubMed (original) (raw)
Schistosoma mansoni: eicosanoid production by cercariae
A C Fusco et al. Exp Parasitol. 1985 Feb.
Abstract
Cercariae of Schistosoma mansoni are stimulated to penetrate skin by certain free fatty acids. The cercariae have an active arachidonate cascade, presumably using host skin essential fatty acids as cascade precursors. Exposing cercariae to 3.3 mM linoleate for 1, 10, and 60 min resulted in production of a wide variety of eicosanoids. Using high-performance liquid chromatography, eicosanoids coeluting with prostaglandin E2, D2, and A2, leukotriene B4, and 5-hydroxyeicosatetraenoic acid standards were identified, as well as unidentified peak positions. Radioimmunoassay confirmed the presence of immunoreactive prostaglandin E1, and E2, and 5- and 15-hydroxyeicosatetraenoic acids in cercarial extracts. No eicosanoid production occurred when cercariae were exposed to 3.3 mM oleate and 1 or 330 microM linoleate. Both high-performance liquid chromatography and radioimmunoassay data indicated that cercariae regulate the production of eicosanoids through time. It is postulated that arachidonate metabolism and subsequent eicosanoid production are required for successful cercarial penetration.
Similar articles
- Schistosoma mansoni: cercarial eicosanoid production and penetration response inhibited by esculetin and ibuprofen.
Salafsky B, Fusco AC. Salafsky B, et al. Exp Parasitol. 1985 Aug;60(1):73-81. doi: 10.1016/s0014-4894(85)80024-2. Exp Parasitol. 1985. PMID: 2990990 - Schistosoma mansoni: production of cercarial eicosanoids as correlates of penetration and transformation.
Fusco AC, Salafsky B, Delbrook K. Fusco AC, et al. J Parasitol. 1986 Jun;72(3):397-404. J Parasitol. 1986. PMID: 3746561 - Schistosoma mansoni: correlations between mouse strain, skin eicosanoid production, and cercarial skin penetration.
Fusco AC, Salafsky B, Ellenberger B, Li LH. Fusco AC, et al. J Parasitol. 1988 Apr;74(2):253-61. J Parasitol. 1988. PMID: 2833595 - Eicosanoids as regulators of pancreatic islet hormone secretion.
Pek SB, Walsh MF. Pek SB, et al. Adv Prostaglandin Thromboxane Leukot Res. 1985;13:221-30. Adv Prostaglandin Thromboxane Leukot Res. 1985. PMID: 2988311 Review. No abstract available.
Cited by
- Endogenous PGD2 acting on DP2 receptor counter regulates Schistosoma mansoni infection-driven hepatic granulomatous fibrosis.
Pezzella-Ferreira GN, Pão CRR, Bellas I, Luna-Gomes T, Muniz VS, Paiva LA, Amorim NRT, Canetti C, Bozza PT, Diaz BL, Bandeira-Melo C. Pezzella-Ferreira GN, et al. PLoS Pathog. 2024 Aug 22;20(8):e1011812. doi: 10.1371/journal.ppat.1011812. eCollection 2024 Aug. PLoS Pathog. 2024. PMID: 39173086 Free PMC article. - Parasitic infections: A new frontier for PGD2 functions.
Diaz BL, Bandeira-Melo C. Diaz BL, et al. Curr Res Immunol. 2024 May 25;5:100078. doi: 10.1016/j.crimmu.2024.100078. eCollection 2024. Curr Res Immunol. 2024. PMID: 38826690 Free PMC article. Review. - Density-Dependent Prophylaxis in Freshwater Snails Driven by Oxylipin Chemical Cues.
Friesen OC, Li CH, Sykes EME, Stout JM, Aukema HM, Kumar A, Detwiler JT. Friesen OC, et al. Front Immunol. 2022 Jan 31;13:826500. doi: 10.3389/fimmu.2022.826500. eCollection 2022. Front Immunol. 2022. PMID: 35173735 Free PMC article. - Schistosome immunomodulators.
Acharya S, Da'dara AA, Skelly PJ. Acharya S, et al. PLoS Pathog. 2021 Dec 30;17(12):e1010064. doi: 10.1371/journal.ppat.1010064. eCollection 2021 Dec. PLoS Pathog. 2021. PMID: 34969052 Free PMC article. Review. - Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions.
Oyesola OO, Tait Wojno ED. Oyesola OO, et al. Eur J Immunol. 2021 Oct;51(10):2399-2416. doi: 10.1002/eji.202048909. Epub 2021 Sep 7. Eur J Immunol. 2021. PMID: 34396535 Free PMC article. Review.