Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate - PubMed (original) (raw)

Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate

H S Hansen et al. Biochim Biophys Acta. 1985.

Abstract

Essential fatty acid-deficient rats were supplemented with 300 mg per day of pure fatty acid esters: oleate (O), linoleate (L), arachidonate (A), and columbinate (C) for 10 days. During this period, the rats in groups L, A, and C all showed a decrease in their initially high trans-epidermal water loss, a classical essential fatty acid-deficiency symptom, to a level seen in non-deficient rats (group N). The trans-epidermal water loss in rats of group O was unaffected by the supplementation. Fatty acid composition of two epidermal sphingolipids, acylglucosylceramide and acylceramide, from the skin were determined. The results indicate that re-establishment of a low trans-epidermal water loss was associated with incorporation of linolenate into the two epidermal sphingolipids. Supplementation with columbinate resulted in relatively high amounts of this fatty acid in the investigated epidermal sphingolipids. Analysis of pooled skin specimens from a previous study in which weanling rats were fed a fat-free diet and supplemented orally with pure alpha-linolenate for 13 weeks (Hansen, H.S. and Jensen, B. (1983) Lipids 18, 682-690) revealed very little polyunsaturated fatty acid in the two sphingolipids. These rats showed increased evaporation which was comparable to that of essential fatty acid-deficient rats. We interpret these results as strong evidence for a very specific and essential function of linoleic acid in maintaining the integrity of the epidermal water permeability barrier. This function of linoleate is independent of its role as precursor for arachidonate and icosanoids.

PubMed Disclaimer

Cited by

Linoleic Acid Induces Metabolic Reprogramming and Inhibits Oxidative and Inflammatory Effects in Keratinocytes Exposed to UVB Radiation.
Manosalva C, Bahamonde C, Soto F, Leal V, Ojeda C, Cortés C, Alarcón P, Burgos RA. Manosalva C, et al. Int J Mol Sci. 2024 Sep 26;25(19):10385. doi: 10.3390/ijms251910385. Int J Mol Sci. 2024. PMID: 39408715 Free PMC article.
Eobania vermiculata whole-body muscle extract-loaded chitosan nanoparticles enhanced skin regeneration and decreased pro-inflammatory cytokines in vivo.
Farid A, Ooda A, Nabil A, Nasser A, Ahmed E, Ali F, Mohamed F, Farid H, Badran M, Ahmed M, Ibrahim M, Rasmy M, Saleeb M, Riad V, Ibrahim Y, Madbouly N. Farid A, et al. J Nanobiotechnology. 2023 Oct 13;21(1):373. doi: 10.1186/s12951-023-02143-3. J Nanobiotechnology. 2023. PMID: 37828599 Free PMC article.
Linoleic Acid Induced Changes in SZ95 Sebocytes-Comparison with Palmitic Acid and Arachidonic Acid.
Kovács D, Camera E, Póliska S, Cavallo A, Maiellaro M, Dull K, Gruber F, Zouboulis CC, Szegedi A, Törőcsik D. Kovács D, et al. Nutrients. 2023 Jul 26;15(15):3315. doi: 10.3390/nu15153315. Nutrients. 2023. PMID: 37571253 Free PMC article.
Current knowledge of the implication of lipid mediators in psoriasis.
Simard M, Morin S, Ridha Z, Pouliot R. Simard M, et al. Front Immunol. 2022 Aug 26;13:961107. doi: 10.3389/fimmu.2022.961107. eCollection 2022. Front Immunol. 2022. PMID: 36091036 Free PMC article. Review.
Vegetable Butters and Oils as Therapeutically and Cosmetically Active Ingredients for Dermal Use: A Review of Clinical Studies.
Poljšak N, Kočevar Glavač N. Poljšak N, et al. Front Pharmacol. 2022 Apr 25;13:868461. doi: 10.3389/fphar.2022.868461. eCollection 2022. Front Pharmacol. 2022. PMID: 35548366 Free PMC article. Review.

Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate - PubMed (original) (raw)