Correcting an immune-response deficiency by creating E alpha gene transgenic mice - PubMed (original) (raw)
. 1985 Jul;316(6023):38-42.
doi: 10.1038/316038a0.
- PMID: 3925351
- DOI: 10.1038/316038a0
Correcting an immune-response deficiency by creating E alpha gene transgenic mice
M Le Meur et al. Nature. 1985 Jul.
Abstract
We have introduced a cloned Ek alpha gene into embryos of mice incapable of expressing their endogenous E alpha genes. The transcription of Ek alpha was accurate and tissue-specific in the resulting transgenic lines and, in macrophages, Ek alpha transcription could be induced by gamma-interferon. The injected gene conferred on the genetically deficient host strain the ability to mount an immune response to a synthetic polymer.
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