A nonmitogenic pituitary function of fibroblast growth factor: regulation of thyrotropin and prolactin secretion - PubMed (original) (raw)
A nonmitogenic pituitary function of fibroblast growth factor: regulation of thyrotropin and prolactin secretion
A Baird et al. Proc Natl Acad Sci U S A. 1985 Aug.
Abstract
The addition of fibroblast growth factor (FGF) to primary cultures of rat anterior pituitary cells modifies their response to thyrotropin-releasing factor in a dose-dependent manner. While the pituitary response to the other releasing factors (corticotropin-releasing factor, growth hormone-releasing factor, and gonadotropin-releasing factor) is not altered, FGF increases both the sensitivity of the cells to thyrotropin-releasing factor and the amounts of prolactin and thyrotropin released. A minimum of 24 hr of preincubation with FGF is required to modify the pituitary response, and maximal effects were observed with 48 and 72 hr of preincubation. The effective doses of FGF are similar to those described for its mitogenic activity (i.e., 1-100 pM), but inhibition of cell growth with 5-fluorodeoxyuridine does not modify the effect of FGF on thyrotropin and prolactin release. These results suggest a novel paracrine, if not autocrine, role of pituitary FGF in the homeostatic mechanisms that regulate the secretion of prolactin and thyrotropin. They also suggest that the biological significance of the presence of FGF in various tissues may not be directly related to its in vitro mitogenic activity.
Similar articles
- Studies on the conditions determining the inhibitory effect of somatostatin on adrenocorticotropin, prolactin and thyrotropin release by cultured rat pituitary cells.
Lamberts SW, Zuyderwijk J, den Holder F, van Koetsveld P, Hofland L. Lamberts SW, et al. Neuroendocrinology. 1989 Jul;50(1):44-50. doi: 10.1159/000125200. Neuroendocrinology. 1989. PMID: 2569172 - Failure to demonstrate the effect of various pre-pro-TRH fragments on TSH and PRL release from rat pituitary in vitro.
Mitsuma T, Hirooka Y, Kimura M, Nogimori T. Mitsuma T, et al. Endocrinol Exp. 1990 Sep;24(3):333-9. Endocrinol Exp. 1990. PMID: 2121460 - Hypothalamic control of prolactin and thyrotropin secretion in teleosts, with special reference to recent studies on the goldfish.
Peter RE, McKeown BA. Peter RE, et al. Gen Comp Endocrinol. 1975 Feb;25(2):153-65. doi: 10.1016/0016-6480(75)90186-0. Gen Comp Endocrinol. 1975. PMID: 807502 Review. No abstract available. - Applications of adenohypophyseal cell cultures to neuroendocrine studies.
Vale W, Rivier C, Brown M, Chan L, Ling N, Rivier J. Vale W, et al. Curr Top Mol Endocrinol. 1976;3:397-429. doi: 10.1007/978-1-4684-2598-7_23. Curr Top Mol Endocrinol. 1976. PMID: 28908 Review. No abstract available.
Cited by
- Folliculostellate cells of the pituitary.
Marin F, Stefaneanu L, Kovacs K. Marin F, et al. Endocr Pathol. 1991 Dec;2(4):180-192. doi: 10.1007/BF02915206. Endocr Pathol. 1991. PMID: 32138407 Review. - Potential role of cytotoxic T-lymphocyte antigen 2 alpha in secretory activity of endocrine cells in mouse adenohypophysis.
Luziga C. Luziga C. Open Vet J. 2019 Jul;9(2):114-119. doi: 10.4314/ovj.v9i2.4. Epub 2019 Apr 12. Open Vet J. 2019. PMID: 31360649 Free PMC article. - Antibody array strategy for human growth factor secretome profiling of GH-secreting adenomas.
Ozeri O, Cohen ZR, Hadani M, Nass D, Shimon I, Rubinfeld H. Ozeri O, et al. Pituitary. 2019 Aug;22(4):344-352. doi: 10.1007/s11102-019-00955-x. Pituitary. 2019. PMID: 30895501 - Thyrotropin-secreting pituitary adenomas: epidemiology, diagnosis, and management.
Amlashi FG, Tritos NA. Amlashi FG, et al. Endocrine. 2016 Jun;52(3):427-40. doi: 10.1007/s12020-016-0863-3. Epub 2016 Jan 21. Endocrine. 2016. PMID: 26792794 Review. - Ras-dva is a novel Pit-1- and glucocorticoid-regulated gene in the embryonic anterior pituitary gland.
Ellestad LE, Porter TE. Ellestad LE, et al. Endocrinology. 2013 Jan;154(1):308-19. doi: 10.1210/en.2012-1566. Epub 2012 Nov 16. Endocrinology. 2013. PMID: 23161868 Free PMC article.
References
- Endocrinology. 1972 Sep;91(3):784-92 - PubMed
- Arch Biol (Liege). 1963;74:439-553 - PubMed
- Clin Chem. 1974 Oct;20(10):1255-70 - PubMed
- Am J Physiol. 1978 Aug;235(2):E97-102 - PubMed
- Annu Rev Physiol. 1979;41:571-85 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources