Borna disease virus. A possible etiologic factor in human affective disorders? - PubMed (original) (raw)

Case Reports

Borna disease virus. A possible etiologic factor in human affective disorders?

J D Amsterdam et al. Arch Gen Psychiatry. 1985 Nov.

Abstract

Borna disease virus is a unique neurotropic agent that appears to have a predilection for the limbic area of the brain. In some animal species, it can produce a behavioral syndrome characterized by aggressive and passive phases. This syndrome has suggested an analogy to certain human affective disorders. In this preliminary study, we examined the possible involvement of Borna disease virus in the etiology of human mood disorders by assaying for virus-specific antibodies in 265 patients with unipolar or bipolar depression and 105 normal, healthy volunteers. Twelve patients (4.5%) and none of the healthy controls demonstrated this antibody in their serum samples. It will be necessary to replicate and extend these intriguing preliminary results to determine if Borna disease virus is possibly involved in the pathogenesis of affective disorders in humans.

PubMed Disclaimer

Similar articles

• Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders.
  Rott R, Herzog S, Fleischer B, Winokur A, Amsterdam J, Dyson W, Koprowski H. Rott R, et al. Science. 1985 May 10;228(4700):755-6. doi: 10.1126/science.3922055. Science. 1985. PMID: 3922055
• Detection of Borna disease virus-reactive antibodies from patients with affective disorders by western immunoblot technique.
  Fu ZF, Amsterdam JD, Kao M, Shankar V, Koprowski H, Dietzschold B. Fu ZF, et al. J Affect Disord. 1993 Jan;27(1):61-8. doi: 10.1016/0165-0327(93)90098-5. J Affect Disord. 1993. PMID: 8432962
• Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies--the key marker triplet determining infection and prevailing in severe mood disorders.
  Bode L, Reckwald P, Severus WE, Stoyloff R, Ferszt R, Dietrich DE, Ludwig H. Bode L, et al. Mol Psychiatry. 2001 Jul;6(4):481-91. doi: 10.1038/sj.mp.4000909. Mol Psychiatry. 2001. PMID: 11443538
• Molecular and immunopathological studies of borna disease virus infection in rats.
  Richt JA, Vande Woude S, Zink MC, Clements JE, Herzog S, Frese K, Stitz L, Narayan O. Richt JA, et al. Behring Inst Mitt. 1991 Jul;(89):163-76. Behring Inst Mitt. 1991. PMID: 1930095 Review.
• Human Borna disease virus-infection and its therapy in affective disorders.
  Dietrich DE, Bode L. Dietrich DE, et al. APMIS Suppl. 2008;(124):61-5. doi: 10.1111/j.1600-0463.2008.00m10.x. APMIS Suppl. 2008. PMID: 18771101 Review.

Cited by

• Ribavirin Treatment for Severe Schizophrenia with Anti-Borna Disease Virus 1 Antibodies 30 Years after Onset.
  Matsunaga H, Fukumori A, Mori K, Morihara T, Sato S, Kitauchi K, Yanagida K, Taguchi K, Honda T, Tomonaga K. Matsunaga H, et al. Case Rep Psychiatry. 2023 Feb 27;2023:4899364. doi: 10.1155/2023/4899364. eCollection 2023. Case Rep Psychiatry. 2023. PMID: 36891160 Free PMC article.
• Back to the Future: The Role of Infections in Psychopathology. Focus on OCD.
  Della Vecchia A, Marazziti D. Della Vecchia A, et al. Clin Neuropsychiatry. 2022 Aug;19(4):248-263. doi: 10.36131/cnfioritieditore20220407. Clin Neuropsychiatry. 2022. PMID: 36101642 Free PMC article.
• Infections, inflammation, and risk of neuropsychiatric disorders: the neglected role of "co-infection".
  Abdoli A, Taghipour A, Pirestani M, Mofazzal Jahromi MA, Roustazadeh A, Mir H, Ardakani HM, Kenarkoohi A, Falahi S, Karimi M. Abdoli A, et al. Heliyon. 2020 Dec 8;6(12):e05645. doi: 10.1016/j.heliyon.2020.e05645. eCollection 2020 Dec. Heliyon. 2020. PMID: 33319101 Free PMC article. Review.
• Synaptic Plasticity and Neurological Disorders in Neurotropic Viral Infections.
  Atluri VS, Hidalgo M, Samikkannu T, Kurapati KR, Nair M. Atluri VS, et al. Neural Plast. 2015;2015:138979. doi: 10.1155/2015/138979. Epub 2015 Nov 16. Neural Plast. 2015. PMID: 26649202 Free PMC article. Review.
• Meta-analysis of infectious agents and depression.
  Wang X, Zhang L, Lei Y, Liu X, Zhou X, Liu Y, Wang M, Yang L, Zhang L, Fan S, Xie P. Wang X, et al. Sci Rep. 2014 Mar 31;4:4530. doi: 10.1038/srep04530. Sci Rep. 2014. PMID: 24681753 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems