Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product - PubMed (original) (raw)
Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product
K V Anderson et al. Cell. 1985 Oct.
Abstract
Within the group of maternal effect genes necessary for the establishment of the dorsal-ventral pattern of the Drosophila embryo, the Toll gene mutates to give a singular variety of embryonic phenotypes. Lack of function alleles produce dorsalized embryos as a recessive maternal effect. Dominant gain of function alleles result in ventralized embryos. Other recessive alleles cause partial dorsalization or lateralization of the embryonic pattern. Gene dosage studies indicate that the dominant ventralized phenotype results from an altered activity of the Toll product. Complementation studies show specific trans interactions between copies of the Toll product. Double mutant phenotypes suggest that the products of several other dorsal-group genes regulate the activity of Toll.
Similar articles
- Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product.
Anderson KV, Bokla L, Nüsslein-Volhard C. Anderson KV, et al. Cell. 1985 Oct;42(3):791-8. doi: 10.1016/0092-8674(85)90275-2. Cell. 1985. PMID: 3931919 - cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos.
Roth S, Hiromi Y, Godt D, Nüsslein-Volhard C. Roth S, et al. Development. 1991 Jun;112(2):371-88. doi: 10.1242/dev.112.2.371. Development. 1991. PMID: 1794309 - The role of easter, an apparent serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo.
Chasan R, Anderson KV. Chasan R, et al. Cell. 1989 Feb 10;56(3):391-400. doi: 10.1016/0092-8674(89)90242-0. Cell. 1989. PMID: 2492450 - Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.
Schneider DS, Hudson KL, Lin TY, Anderson KV. Schneider DS, et al. Genes Dev. 1991 May;5(5):797-807. doi: 10.1101/gad.5.5.797. Genes Dev. 1991. PMID: 1827421 - [Determination of the dorso-ventral polarity of the Drosophila embryo].
Mohier E. Mohier E. Ann Genet. 1993;36(1):5-15. Ann Genet. 1993. PMID: 8503650 Review. French.
Cited by
- Striking parallels between dorsoventral patterning in Drosophila and Gryllus reveal a complex evolutionary history behind a model gene regulatory network.
Pechmann M, Kenny NJ, Pott L, Heger P, Chen YT, Buchta T, Özüak O, Lynch J, Roth S. Pechmann M, et al. Elife. 2021 Mar 30;10:e68287. doi: 10.7554/eLife.68287. Elife. 2021. PMID: 33783353 Free PMC article. - Emerging role of Toll-like receptors in the control of pain and itch.
Liu T, Gao YJ, Ji RR. Liu T, et al. Neurosci Bull. 2012 Apr;28(2):131-44. doi: 10.1007/s12264-012-1219-5. Neurosci Bull. 2012. PMID: 22466124 Free PMC article. Review. - A reaction-diffusion network model predicts a dual role of Cactus/IκB to regulate Dorsal/NFκB nuclear translocation in Drosophila.
Barros CDT, Cardoso MA, Bisch PM, Araujo HM, Lopes FJP. Barros CDT, et al. PLoS Comput Biol. 2021 May 27;17(5):e1009040. doi: 10.1371/journal.pcbi.1009040. eCollection 2021 May. PLoS Comput Biol. 2021. PMID: 34043616 Free PMC article. - The 'ubiquitous' reality of vector immunology.
Severo MS, Sakhon OS, Choy A, Stephens KD, Pedra JH. Severo MS, et al. Cell Microbiol. 2013 Jul;15(7):1070-8. doi: 10.1111/cmi.12128. Epub 2013 Mar 14. Cell Microbiol. 2013. PMID: 23433059 Free PMC article. Review. - Functional identification of dendritic cells in the teleost model, rainbow trout (Oncorhynchus mykiss).
Bassity E, Clark TG. Bassity E, et al. PLoS One. 2012;7(3):e33196. doi: 10.1371/journal.pone.0033196. Epub 2012 Mar 12. PLoS One. 2012. PMID: 22427987 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases