Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product - PubMed (original) (raw)
Comparative Study
Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product
K V Anderson et al. Cell. 1985 Oct.
Abstract
Drosophila females that lack Toll gene activity produce dorsalized embryos, in which all embryonic cells behave like the dorsal cells of the wild-type embryo. Injection of wild-type cytoplasm into young Toll- embryos restores their ability to produce a normal dorsal-ventral pattern in a position-dependent manner. No matter where the cytoplasm is injected relative to the dorsal-ventral axis of the egg shell, the position of the injected cytoplasm defines the ventralmost part of the rescued pattern. Although injection of wild-type cytoplasm into mutants at six other dorsal-group loci also restores the ability to produce lateral and ventral structures, only Toll- embryos lack any residual dorsal-ventral polarity. Experiments suggest that the activity of the Toll product is normally regulated by other dorsal-group genes and that the function of the Toll product is to provide the source for a morphogen gradient in the dorsal-ventral axis of the wild-type embryo.
Similar articles
- Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product.
Anderson KV, Jürgens G, Nüsslein-Volhard C. Anderson KV, et al. Cell. 1985 Oct;42(3):779-89. doi: 10.1016/0092-8674(85)90274-0. Cell. 1985. PMID: 3931918 - Isolation of the dorsal locus of Drosophila.
Steward R, McNally FJ, Schedl P. Steward R, et al. Nature. 1984 Sep 20-26;311(5983):262-5. doi: 10.1038/311262a0. Nature. 1984. PMID: 6434990 - Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.
Schneider DS, Hudson KL, Lin TY, Anderson KV. Schneider DS, et al. Genes Dev. 1991 May;5(5):797-807. doi: 10.1101/gad.5.5.797. Genes Dev. 1991. PMID: 1827421 - [Determination of the dorso-ventral polarity of the Drosophila embryo].
Mohier E. Mohier E. Ann Genet. 1993;36(1):5-15. Ann Genet. 1993. PMID: 8503650 Review. French. - Establishment of dorsal-ventral and terminal pattern in the Drosophila embryo.
Stein DS, Stevens LM. Stein DS, et al. Curr Opin Genet Dev. 1991 Aug;1(2):247-54. doi: 10.1016/s0959-437x(05)80078-4. Curr Opin Genet Dev. 1991. PMID: 1688006 Review.
Cited by
- Expression and Function of Toll Pathway Components in the Early Development of the Wasp Nasonia vitripennis.
Pers D, Buchta T, Özüak O, Roth S, Lynch JA. Pers D, et al. J Dev Biol. 2022 Jan 26;10(1):7. doi: 10.3390/jdb10010007. J Dev Biol. 2022. PMID: 35225961 Free PMC article. - Toll-like Receptors and the Control of Immunity.
Fitzgerald KA, Kagan JC. Fitzgerald KA, et al. Cell. 2020 Mar 19;180(6):1044-1066. doi: 10.1016/j.cell.2020.02.041. Epub 2020 Mar 11. Cell. 2020. PMID: 32164908 Free PMC article. Review. - An anteroposterior Dorsal gradient in the Drosophila embryo.
Huang AM, Rusch J, Levine M. Huang AM, et al. Genes Dev. 1997 Aug 1;11(15):1963-73. doi: 10.1101/gad.11.15.1963. Genes Dev. 1997. PMID: 9271119 Free PMC article. - Trial Watch: Toll-like receptor agonists in oncological indications.
Aranda F, Vacchelli E, Obrist F, Eggermont A, Galon J, Sautès-Fridman C, Cremer I, Henrik Ter Meulen J, Zitvogel L, Kroemer G, Galluzzi L. Aranda F, et al. Oncoimmunology. 2014 Aug 1;3:e29179. doi: 10.4161/onci.29179. eCollection 2014. Oncoimmunology. 2014. PMID: 25083332 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases