Alterations of myc, myb, and rasHa proto-oncogenes in cancers are frequent and show clinical correlation - PubMed (original) (raw)

Alterations of myc, myb, and rasHa proto-oncogenes in cancers are frequent and show clinical correlation

J Yokota et al. Science. 1986.

Abstract

Alterations of c-myc, c-rasHa, or c-myb oncogenes were found in more than one-third of human solid tumors. Amplification of c-myc occurred in advanced, widespread tumors or in aggressive primary tumors. Apparent allelic deletions of c-rasHa and c-myb can be correlated with progression and metastasis of carcinomas and sarcomas.

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