Increased production of aminoglycosides associated with amplified antibiotic resistance genes - PubMed (original) (raw)
Increased production of aminoglycosides associated with amplified antibiotic resistance genes
R Crameri et al. J Antibiot (Tokyo). 1986 Jan.
Free article
Abstract
The 6'-N-acetyltransferase derived from Streptomyces kanamyceticus strain M1164 was cloned on to the high copy plasmid vector pIJ702 and introduced into S. kanamyceticus (ATCC 12853, a kanamycin producer) and S. fradiae (ATCC 10745, a neomycin producer). In both cases transformants containing the recombinant plasmid showed increased resistance to a number of aminoglycoside antibiotics and substantially increased production of kanamycin and neomycin. This demonstrates that specific amplification of gene products associated with antibiotic biosynthesis provides a means for improving antibiotic production.
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