Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones

A A Harper et al. J Physiol. 1985 Feb.

Abstract

Combining intracellular recording and dye-injection techniques permitted direct correlation of neuronal soma size with peripheral nerve conduction velocity in individual neurones of the L4 dorsal root ganglion (d.r.g.) of the anaesthetized 5-8-week-old rat. The conduction velocities fell into two main groups; those greater than 14 m/s (A alpha and beta fibres) and those less than 8 m/s (A delta and C fibres). Fibres with conduction velocities in the A delta range (2.2-8 m/s) in the sciatic nerve between the sciatic notch and the neuronal soma in the d.r.g. often conducted more slowly, that is in the C-fibre range (less than 1.4 m/s), in the periphery from the tibial nerve to the sciatic notch. For the fast-conducting myelinated afferents, there was a loose positive correlation between cell size and the conduction velocity of the peripheral axon, whereas a clearer positive correlation existed between neuronal cell size and axonal conduction velocity both for A delta- and for C-fibre afferents. The relationship of the cell cross-sectional area (measured at the nucleolar level), to the cell volume for each neuronal soma was similar for the different conduction velocity groups. The somata of the fast-conducting myelinated A alpha and A beta fibres had a similar mean and range of cross-sectional areas to those of the large light cell population. The somata with A delta and C fibres were of a more uniform size and were restricted to the smaller cells within the ganglia. The mean and range of cross-sectional areas of the C cells was similar to those of the small dark cell population. A delta somata had a larger mean and range of cell sizes than those of the small dark cell population. The relationships of peripheral axon type to the morphological cell types are discussed.

PubMed Disclaimer

Cited by

Expression and function of a CP339,818-sensitive K⁺ current in a subpopulation of putative nociceptive neurons from adult mouse trigeminal ganglia.
Sforna L, D'Adamo MC, Servettini I, Guglielmi L, Pessia M, Franciolini F, Catacuzzeno L. Sforna L, et al. J Neurophysiol. 2015 Apr 1;113(7):2653-65. doi: 10.1152/jn.00379.2014. Epub 2015 Feb 4. J Neurophysiol. 2015. PMID: 25652918 Free PMC article.
Soma neurofilament immunoreactivity is related to cell size and fibre conduction velocity in rat primary sensory neurons.
Lawson SN, Waddell PJ. Lawson SN, et al. J Physiol. 1991 Apr;435:41-63. doi: 10.1113/jphysiol.1991.sp018497. J Physiol. 1991. PMID: 1770443 Free PMC article.
delta opioid receptor modulation of several voltage-dependent Ca(2+) currents in rat sensory neurons.
Acosta CG, López HS. Acosta CG, et al. J Neurosci. 1999 Oct 1;19(19):8337-48. doi: 10.1523/JNEUROSCI.19-19-08337.1999. J Neurosci. 1999. PMID: 10493735 Free PMC article.
Expression of G protein-coupled receptor 30 in the spinal somatosensory system.
Takanami K, Sakamoto H, Matsuda K, Hosokawa K, Nishi M, Prossnitz ER, Kawata M. Takanami K, et al. Brain Res. 2010 Jan 15;1310:17-28. doi: 10.1016/j.brainres.2009.11.004. Epub 2009 Nov 11. Brain Res. 2010. PMID: 19912997 Free PMC article.
Multiple sites for generation of ectopic spontaneous activity in neurons of the chronically compressed dorsal root ganglion.
Ma C, LaMotte RH. Ma C, et al. J Neurosci. 2007 Dec 19;27(51):14059-68. doi: 10.1523/JNEUROSCI.3699-07.2007. J Neurosci. 2007. PMID: 18094245 Free PMC article.

References

1. Kaibogaku Zasshi. 1970 Aug 1;45(4):191-205 - PubMed
1. J Comp Neurol. 1956 Feb;104(1):1-16 - PubMed
1. J Comp Neurol. 1973 Feb 15;147(4):547-52 - PubMed
1. Anat Rec. 1973 Jun;176(2):225-43 - PubMed
1. Cell Tissue Res. 1974;153(3):399-413 - PubMed

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources
- PubMed Central
- Wiley
Other Literature Sources
- The Lens - Patent Citations Database

Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones - PubMed (original) (raw)