Nucleotide sequence of a full-length human endogenous retroviral segment - PubMed (original) (raw)
Nucleotide sequence of a full-length human endogenous retroviral segment
R Repaske et al. J Virol. 1985 Jun.
Abstract
The nucleotide sequence of a full-length (8.8-kilobase) endogenous C-type human retroviral DNA (clone 4-1) is presented and compared with that of Moloney murine leukemia virus (MoMuLV) DNA. Colinearity of deduced amino acids of clone 4-1 with MoMuLV in the gag and pol regions was clearly evident, and overall amino acid homology in these regions was about 40%. Identification of the putative N terminus of gag and p30, the gag-pol junction, and the C terminus of pol could be established on the basis of sequence homology with MoMuLV. Unique characteristics of the endogenous human retroviral DNA included a tRNA Glu primer binding site separated from the 5' long terminal repeat by a pentanucleotide and a putative env sequence which does not appear to overlap the C terminus of pol and has virtually no homology with the env gene of known infectious retroviruses. Clone 4-1 represents a defective prototype of a human C-type retrovirus which integrated into the germ line some time in the distant past.
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References
- Virology. 1977 Mar;77(1):413-7 - PubMed
- Proc Natl Acad Sci U S A. 1984 Dec;81(23):7363-7 - PubMed
- Methods Enzymol. 1980;65(1):595-609 - PubMed
- Cell. 1981 Mar;23(3):643-6 - PubMed
- Nucleic Acids Res. 1981 May 25;9(10):2239-50 - PubMed
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