Radial distribution of white cells during blood flow in small tubes - PubMed (original) (raw)
Radial distribution of white cells during blood flow in small tubes
U Nobis et al. Microvasc Res. 1985 May.
Abstract
The radial distribution of white blood cells (WBC) in blood flowing through glass tubes (i.d. 69 micron) was studied as a function of wall shear stress (range 0.1-2.5 Pa) and suspending medium (plasma, buffered saline, high-molecular-weight dextran solution). It was found that, irrespective of the choice of suspending medium, the highest leukocyte flux at high shear stresses was found in the tube center. WBC redistribution was seen upon lowering the shear stresses: A significant shift of WBC flux toward the marginal fluid layers occurred at the expense of the axial region. After replacement of plasma by other media the flow-dependent redistribution of WBCs was qualitatively unaffected. However, suspension of cells in dextran solution (inducing strong red cell aggregation) resulted in enhanced WBC margination, while in saline (no red cell aggregation) axial accumulation was accentuated. The results support the concept of size-dependent radial distribution of particles in flow of mixed suspensions. If applied to the living microcirculation, the data serve to explain WBC margination in microvessels (the first step in the series of events leading to emigration) in terms of a hydrodynamic phenomenon resulting from red cell/white cell interaction. The pronounced flow dependence of WBC margination results primarily from the effect of shear on red cell aggregation which leads to an alteration of the effective particle size distribution in the flowing blood.
Similar articles
- Effect of fibrinogen on leukocyte margination and adhesion in postcapillary venules.
Pearson MJ, Lipowsky HH. Pearson MJ, et al. Microcirculation. 2004 Apr-May;11(3):295-306. doi: 10.1080/10739680490425994. Microcirculation. 2004. PMID: 15280083 - Influence of erythrocyte aggregation on leukocyte margination in postcapillary venules of rat mesentery.
Pearson MJ, Lipowsky HH. Pearson MJ, et al. Am J Physiol Heart Circ Physiol. 2000 Oct;279(4):H1460-71. doi: 10.1152/ajpheart.2000.279.4.H1460. Am J Physiol Heart Circ Physiol. 2000. PMID: 11009430 - Margination of white blood cells in microcapillary flow.
Fedosov DA, Fornleitner J, Gompper G. Fedosov DA, et al. Phys Rev Lett. 2012 Jan 13;108(2):028104. doi: 10.1103/PhysRevLett.108.028104. Epub 2012 Jan 11. Phys Rev Lett. 2012. PMID: 22324714 - Disturbed blood flow structuring as critical factor of hemorheological disorders in microcirculation.
Mchedlishvili G. Mchedlishvili G. Clin Hemorheol Microcirc. 1998 Dec;19(4):315-25. Clin Hemorheol Microcirc. 1998. PMID: 9972669 Review. - The role of the white blood cell in arterial disease.
Belch JJ. Belch JJ. Blood Coagul Fibrinolysis. 1990 Jun;1(2):183-91. Blood Coagul Fibrinolysis. 1990. PMID: 2130930 Review.
Cited by
- In Vitro Measurements of Cellular Forces and their Importance in the Lung-From the Sub- to the Multicellular Scale.
Kolb P, Schundner A, Frick M, Gottschalk KE. Kolb P, et al. Life (Basel). 2021 Jul 14;11(7):691. doi: 10.3390/life11070691. Life (Basel). 2021. PMID: 34357063 Free PMC article. Review. - Vascularized Microfluidics and the Blood-Endothelium Interface.
Hesh CA, Qiu Y, Lam WA. Hesh CA, et al. Micromachines (Basel). 2019 Dec 23;11(1):18. doi: 10.3390/mi11010018. Micromachines (Basel). 2019. PMID: 31878018 Free PMC article. Review. - Cellular softening mediates leukocyte demargination and trafficking, thereby increasing clinical blood counts.
Fay ME, Myers DR, Kumar A, Turbyfield CT, Byler R, Crawford K, Mannino RG, Laohapant A, Tyburski EA, Sakurai Y, Rosenbluth MJ, Switz NA, Sulchek TA, Graham MD, Lam WA. Fay ME, et al. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):1987-92. doi: 10.1073/pnas.1508920113. Epub 2016 Feb 8. Proc Natl Acad Sci U S A. 2016. PMID: 26858400 Free PMC article. - Role of the endothelial surface layer in neutrophil recruitment.
Marki A, Esko JD, Pries AR, Ley K. Marki A, et al. J Leukoc Biol. 2015 Oct;98(4):503-15. doi: 10.1189/jlb.3MR0115-011R. Epub 2015 May 15. J Leukoc Biol. 2015. PMID: 25979432 Free PMC article. Review. - A physical sciences network characterization of circulating tumor cell aggregate transport.
King MR, Phillips KG, Mitrugno A, Lee TR, de Guillebon AM, Chandrasekaran S, McGuire MJ, Carr RT, Baker-Groberg SM, Rigg RA, Kolatkar A, Luttgen M, Bethel K, Kuhn P, Decuzzi P, McCarty OJ. King MR, et al. Am J Physiol Cell Physiol. 2015 May 15;308(10):C792-802. doi: 10.1152/ajpcell.00346.2014. Epub 2015 Mar 18. Am J Physiol Cell Physiol. 2015. PMID: 25788574 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Other Literature Sources