Androgen receptor activity in human breast cancer and its relationship with oestrogen and progestogen receptor activity - PubMed (original) (raw)
Androgen receptor activity in human breast cancer and its relationship with oestrogen and progestogen receptor activity
W R Miller et al. Eur J Cancer Clin Oncol. 1985 Apr.
Abstract
Androgen receptor activity was measured in tumours from 122 patients with breast cancer. Forty-two tumours (34%) possessed androgen receptors at levels varying from 17 to 210 fmol/mg cytosol protein (mean value 68). No relationship was detected between androgen receptors and menopausal status of the patients and whether or not lymph nodes were invaded with tumour at the time of biopsy. There were, however, significant positive correlations between the presence of androgen receptors and that of oestrogen (P less than 0.05) and of progestogen receptors (P less than 0.025). These relationships suggest that androgen receptors may be of value in predicting the hormone responsiveness of breast tumours but definitive proof of this requires clinical follow-up of the patients studied.
Similar articles
- Distribution, frequency, and quantitative analysis of estrogen, progesterone, androgen, and glucocorticoid receptors in human breast cancer.
Allegra JC, Lippman ME, Thompson EB, Simon R, Barlock A, Green L, Huff KK, Do HM, Aitken SC. Allegra JC, et al. Cancer Res. 1979 May;39(5):1447-54. Cancer Res. 1979. PMID: 427788 - Simultaneous and sequential determinations of steroid hormone receptors in human breast cancer. Influence of intervening therapy.
Jakesz R, Dittrich C, Hanusch J, Kolb R, Lenzhofer R, Moser K, Rainer H, Reiner G, Schemper M, Spona J, et al. Jakesz R, et al. Ann Surg. 1985 Mar;201(3):305-10. doi: 10.1097/00000658-198503000-00008. Ann Surg. 1985. PMID: 3977430 Free PMC article. - Binding of [3H]-methyltrienolone (R1881) by human breast cancers.
Miller WR, Telford J, Hawkins RA. Miller WR, et al. Eur J Cancer Clin Oncol. 1983 Oct;19(10):1473-8. doi: 10.1016/0277-5379(93)90018-z. Eur J Cancer Clin Oncol. 1983. PMID: 6605855 - Therapeutic significance of sex-steroid hormone receptors in the treatment of breast cancer.
Leclercq G, Heuson JC. Leclercq G, et al. Eur J Cancer (1965). 1977 Nov;13(11):1205-15. doi: 10.1016/0014-2964(77)90026-3. Eur J Cancer (1965). 1977. PMID: 338304 Review. No abstract available. - Steroid receptors in breast tumors--current status.
McGuire WL, Zava DT, Horwitz KB, Chamness GC. McGuire WL, et al. Curr Top Exp Endocrinol. 1978;3:93-129. Curr Top Exp Endocrinol. 1978. PMID: 350504 Review. No abstract available.
Cited by
- Prevalence of Androgen Receptor in Invasive Breast Cancer and Its Association with Clinicopathologic Features in East Azarbaijan Province of Iran: A Cross-Sectional Study.
Nikanfar A, Nikanfar M, Fakhrjou A. Nikanfar A, et al. Int J Hematol Oncol Stem Cell Res. 2023 Jul 1;17(3):186-193. doi: 10.18502/ijhoscr.v17i3.13308. Int J Hematol Oncol Stem Cell Res. 2023. PMID: 37817975 Free PMC article. - Expression of Androgen Receptor in Estrogen Receptor-positive Breast Cancer.
Agrawal A, Ziolkowski P, Grzebieniak Z, Jelen M, Bobinski P, Agrawal S. Agrawal A, et al. Appl Immunohistochem Mol Morphol. 2016 Sep;24(8):550-5. doi: 10.1097/PAI.0000000000000234. Appl Immunohistochem Mol Morphol. 2016. PMID: 26230371 Free PMC article. - Androgen receptor expresion in breast cancer: relationship with clinicopathological characteristics of the tumors, prognosis, and expression of metalloproteases and their inhibitors.
Gonzalez LO, Corte MD, Vazquez J, Junquera S, Sanchez R, Alvarez AC, Rodriguez JC, Lamelas ML, Vizoso FJ. Gonzalez LO, et al. BMC Cancer. 2008 May 28;8:149. doi: 10.1186/1471-2407-8-149. BMC Cancer. 2008. PMID: 18507821 Free PMC article. - The discovery and mechanism of action of letrozole.
Bhatnagar AS. Bhatnagar AS. Breast Cancer Res Treat. 2007;105 Suppl 1(Suppl 1):7-17. doi: 10.1007/s10549-007-9696-3. Epub 2007 Oct 3. Breast Cancer Res Treat. 2007. PMID: 17912633 Free PMC article. Review. - Androgen receptor expression in metastatic adenocarcinoma in females favors a breast primary.
Shidham VB, Komorowski RA, Machhi JK. Shidham VB, et al. Diagn Pathol. 2006 Oct 4;1:34. doi: 10.1186/1746-1596-1-34. Diagn Pathol. 2006. PMID: 17020615 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical