Disturbance of methyl group metabolism in alloxan-diabetic sheep - PubMed (original) (raw)
. 1985 Jun;10(6):897-905.
- PMID: 4038311
Disturbance of methyl group metabolism in alloxan-diabetic sheep
G P Xue et al. Biochem Int. 1985 Jun.
Abstract
Alloxan-induced diabetes results in changes in the activities of a number of enzymes related to methyl group metabolism in sheep. Decreases in the activities of phospholipid methyltransferase and betaine-homocysteine methyltransferase in diabetic sheep liver indicate a reduced rate of choline synthesis and oxidation. A 65-fold increase in the activity of glycine methyltransferase and a 4-fold rise in the activity of gamma-cystathionase in diabetic sheep liver with elevated urinary excretion of cyst(e)ine suggest that catabolism of the methyl group of methionine and homocysteine was enhanced in the diabetic state.