Electrostatic deformation of DNA by a DNA-binding protein - PubMed (original) (raw)
Comparative Study
. 1985 May 25;260(10):5860-2.
- PMID: 4039722
Free article
Comparative Study
Electrostatic deformation of DNA by a DNA-binding protein
J B Matthew et al. J Biol Chem. 1985.
Free article
Abstract
Complementary electrostatic interactions between negatively charged B-DNA and a positively charged array on the lambda Cro repressor protein are shown to substantially contribute to the formation energy of sequence-specific and nonspecific Cro-DNA complexes. The electrostatic interactions favor Cro binding to a bent form of DNA, a geometry which optimizes hydrogen-bonding contacts between Cro and exposed base pair groups in the DNA major groove.