Changes in the prolactin response to thyrotropin-releasing hormone (TRH) during the menstrual cycle of normal women - PubMed (original) (raw)

Changes in the prolactin response to thyrotropin-releasing hormone (TRH) during the menstrual cycle of normal women

A E Boyd 3rd et al. J Clin Endocrinol Metab. 1977 May.

Abstract

Serum prolactin (PRL) and thyrotropin (TSH) levels were measured after iv administration of 200 microng of synthetic thyrotropin-releasing hormone (TRH) in 20 normal women ages 18 to 34. Ten women received TRH on days 7 to 8 of the menstrual cycle and 10 women received TRH on days 21-22. Although there was no difference in the dose of TRH relative to body weight in the two groups of women, the peak PRL level after TRH stimulation was greater in the women studied on day 21-22 (48.5+/-5.7 ng/ml, mean+/-SE) than on day 7-8 (35.2+/-4.2 ng/ml) of the cycle (P less than 0.05). In contrast, TSH rose to a greater degree in the preovulatory phase (13.8+/-1.8 micronU/ml) than the luteal phase (7.7+/-0.7 micronU/ml of the cycle (P less than .01). Studies of the PRL and TSH response after TRH administration should take the phase of the menstrual cycle into account.

PIP: The effects of synthetic thyrotropin-releasing hormone (TRH), administered iv in a dose of 200 mcg, on serum prolactin and thyrotropin levels were measured in 20 women aged 18-34 years. 10 subjects received TRH on Days 7-8 of the menstrual cycle, and the remaining 10 were treated on Days 21-22. The dose/body weight ratio was similar in both groups. The peak prolactin level following TRH administration was 48.5 + or -5.7 ng/ml in women treated on Days 21-22 and 35.2 + or -4.2 ng/ml in those treated on Days 7-8 (p less than .05). Conversely, serum levels of thyrotropin were significantly (p less than .01) higher in the preovulatory phase than the luteal phase (13.8 + or -mcU/ml and 7.7 + or -.7 mcU/ml, respectively). It is recommended that the interpretation of the prolactin response to TRH should take the phase of the menstrual cycle into account.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources