Relationship between metabolic rate, free radicals, differentiation and aging: a unified theory - PubMed (original) (raw)
Relationship between metabolic rate, free radicals, differentiation and aging: a unified theory
R S Sohal et al. Basic Life Sci. 1985.
Abstract
Metabolic rate is a major factor governing the rate of aging in both homeotherms and poikilotherms and is inversely related to life span. Homeotherms exhibit stable basal metabolic rates and species-specific life spans. Conversely, in poikilotherms, both basal metabolic rate and life span vary greatly. Metabolic potential (total energy consumed/g/life span) is a species-specific characteristic in Homoetherms and poikilotherms. Length of life is dependent upon the rate at which this fixed metabolic potential is expended, that is, metabolic rate. Oxygen-free radicals produced by metabolism can cause molecular damage. Accumulation of lipofuscin granules, Schiff-base-like, fluorescent material and thiobarbituric acid-reactants, as well as increased exhalation of pentane with age are indicative of free, radical-induced molecular damage. Metabolic rate influences the rate of age-related changes. There is an overlapping compensatory balance between various components of the antioxidant defense system. The total antioxidant capacity of cells tends to decline with age. A dynamic equilibrium may exist between the rate of free radical generation and antioxidant levels. The establishment of this equilibrium is associated with differentiation. It is hypothesized that loss of the equilibrium between free radical generation and antioxidant defenses results in dysdifferentiation, aging and cancer.
Similar articles
- Relationship between antioxidants, prooxidants, and the aging process.
Sohal RS, Orr WC. Sohal RS, et al. Ann N Y Acad Sci. 1992 Nov 21;663:74-84. doi: 10.1111/j.1749-6632.1992.tb38651.x. Ann N Y Acad Sci. 1992. PMID: 1482104 Review. - Oxidative Stress and the Aging Brain: From Theory to Prevention.
Gemma C, Vila J, Bachstetter A, Bickford PC. Gemma C, et al. In: Riddle DR, editor. Brain Aging: Models, Methods, and Mechanisms. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 15. In: Riddle DR, editor. Brain Aging: Models, Methods, and Mechanisms. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 15. PMID: 21204345 Free Books & Documents. Review. - The free radical hypothesis of aging: an appraisal of the current status.
Sohal RS. Sohal RS. Aging (Milano). 1993 Feb;5(1):3-17. doi: 10.1007/BF03324120. Aging (Milano). 1993. PMID: 8386942 Review. - The aging process.
Harman D. Harman D. Proc Natl Acad Sci U S A. 1981 Nov;78(11):7124-8. doi: 10.1073/pnas.78.11.7124. Proc Natl Acad Sci U S A. 1981. PMID: 6947277 Free PMC article.
Cited by
- Mitochondrial Ca2+ and regulation of the permeability transition pore.
Hurst S, Hoek J, Sheu SS. Hurst S, et al. J Bioenerg Biomembr. 2017 Feb;49(1):27-47. doi: 10.1007/s10863-016-9672-x. Epub 2016 Aug 6. J Bioenerg Biomembr. 2017. PMID: 27497945 Free PMC article. Review. - Calorie Restriction and Aging in Humans.
Flanagan EW, Most J, Mey JT, Redman LM. Flanagan EW, et al. Annu Rev Nutr. 2020 Sep 23;40:105-133. doi: 10.1146/annurev-nutr-122319-034601. Epub 2020 Jun 19. Annu Rev Nutr. 2020. PMID: 32559388 Free PMC article. - Mechanisms of sudden cardiac death: oxidants and metabolism.
Yang KC, Kyle JW, Makielski JC, Dudley SC Jr. Yang KC, et al. Circ Res. 2015 Jun 5;116(12):1937-55. doi: 10.1161/CIRCRESAHA.116.304691. Circ Res. 2015. PMID: 26044249 Free PMC article. Review. - Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit.
Chen Y, Johansson E, Fan Y, Shertzer HG, Vasiliou V, Nebert DW, Dalton TP. Chen Y, et al. Free Radic Biol Med. 2009 Aug 15;47(4):410-8. doi: 10.1016/j.freeradbiomed.2009.05.003. Epub 2009 May 8. Free Radic Biol Med. 2009. PMID: 19427898 Free PMC article. - The epigenetic and morphogenetic effects of molecular oxygen and its derived reactive species in development.
Hitchler MJ, Domann FE. Hitchler MJ, et al. Free Radic Biol Med. 2021 Jul;170:70-84. doi: 10.1016/j.freeradbiomed.2021.01.008. Epub 2021 Jan 12. Free Radic Biol Med. 2021. PMID: 33450377 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical