Correlation between adenosine triphosphate levels, dopamine release and electrical activity in the carotid body: support for the metabolic hypothesis of chemoreception - PubMed (original) (raw)
Correlation between adenosine triphosphate levels, dopamine release and electrical activity in the carotid body: support for the metabolic hypothesis of chemoreception
A Obeso et al. Brain Res. 1985.
Abstract
An unsolved issue for the arterial chemoreceptors is the mechanism by which hypoxia and other natural stimuli lead to an increase of activity in the carotid sinus nerve. According to the 'metabolic hypothesis', the hypoxic activation of the carotid body (CB) is mediated by a decrease of the ATP levels in the type I cells, which then release a neurotransmitter capable of exciting the sensory nerve endings. Using an in vitro preparation of cat CB, we report that ATP levels in the CB do in fact decrease when the organs are exposed to moderate, short lasting hypoxia (5 min 20% O2). Additionally, we found that decreases in ATP levels induced by 2-deoxyglucose (2 mM) or sodium cyanide (0.1 mM) are closely correlated with dopamine release from type I cells and electrical activity in the carotid sinus nerve elicited by these agents. The possible cause-effect relationship of these events is discussed.
Similar articles
- Effects of 2-deoxy-D-glucose on in vitro cat carotid body.
Obeso A, Almaraz L, Gonzalez C. Obeso A, et al. Brain Res. 1986 Apr 16;371(1):25-36. doi: 10.1016/0006-8993(86)90806-1. Brain Res. 1986. PMID: 3708344 - Dissociation of hypoxia-induced chemosensory responses and catecholamine efflux in cat carotid body superfused in vitro.
Iturriaga R, Alcayaga J, Zapata P. Iturriaga R, et al. J Physiol. 1996 Dec 1;497 ( Pt 2)(Pt 2):551-64. doi: 10.1113/jphysiol.1996.sp021788. J Physiol. 1996. PMID: 8961195 Free PMC article. - Hypoxic intensity: a determinant for the contribution of ATP and adenosine to the genesis of carotid body chemosensory activity.
Conde SV, Monteiro EC, Rigual R, Obeso A, Gonzalez C. Conde SV, et al. J Appl Physiol (1985). 2012 Jun;112(12):2002-10. doi: 10.1152/japplphysiol.01617.2011. Epub 2012 Apr 12. J Appl Physiol (1985). 2012. PMID: 22500005 - Cellular mechanisms of oxygen chemoreception in the carotid body.
Gonzalez C, Lopez-Lopez JR, Obeso A, Perez-Garcia MT, Rocher A. Gonzalez C, et al. Respir Physiol. 1995 Dec;102(2-3):137-47. doi: 10.1016/0034-5687(95)00069-0. Respir Physiol. 1995. PMID: 8904006 Review. - Is ATP a suitable co-transmitter in carotid body arterial chemoreceptors?
Zapata P. Zapata P. Respir Physiol Neurobiol. 2007 Jul 1;157(1):106-15. doi: 10.1016/j.resp.2007.01.002. Epub 2007 Jan 11. Respir Physiol Neurobiol. 2007. PMID: 17276149 Review.
Cited by
- Are Multiple Mitochondrial Related Signalling Pathways Involved in Carotid Body Oxygen Sensing?
Holmes AP, Swiderska A, Nathanael D, Aldossary HS, Ray CJ, Coney AM, Kumar P. Holmes AP, et al. Front Physiol. 2022 May 31;13:908617. doi: 10.3389/fphys.2022.908617. eCollection 2022. Front Physiol. 2022. PMID: 35711317 Free PMC article. Review. - Carotid body chemoreceptors: physiology, pathology, and implications for health and disease.
Iturriaga R, Alcayaga J, Chapleau MW, Somers VK. Iturriaga R, et al. Physiol Rev. 2021 Jul 1;101(3):1177-1235. doi: 10.1152/physrev.00039.2019. Epub 2021 Feb 11. Physiol Rev. 2021. PMID: 33570461 Free PMC article. Review. - Purines and Carotid Body: New Roles in Pathological Conditions.
Conde SV, Monteiro EC, Sacramento JF. Conde SV, et al. Front Pharmacol. 2017 Dec 12;8:913. doi: 10.3389/fphar.2017.00913. eCollection 2017. Front Pharmacol. 2017. PMID: 29311923 Free PMC article. Review. - Peripheral chemoreceptors: function and plasticity of the carotid body.
Kumar P, Prabhakar NR. Kumar P, et al. Compr Physiol. 2012 Jan;2(1):141-219. doi: 10.1002/cphy.c100069. Compr Physiol. 2012. PMID: 23728973 Free PMC article. Review. - Carotid body denervation prevents the development of insulin resistance and hypertension induced by hypercaloric diets.
Ribeiro MJ, Sacramento JF, Gonzalez C, Guarino MP, Monteiro EC, Conde SV. Ribeiro MJ, et al. Diabetes. 2013 Aug;62(8):2905-16. doi: 10.2337/db12-1463. Epub 2013 Mar 25. Diabetes. 2013. PMID: 23530003 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous