Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains - PubMed (original) (raw)
Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains
J Silver. J Hered. 1985 Nov-Dec.
Abstract
Recombinant inbred (RI) strains are extremely useful for genetic mapping. This paper presents a simple method for determining confidence intervals for linkage estimates based on analysis of RI strains. The results show that such confidence intervals are usually large with the currently available numbers of RI strains. Therefore, map positions based only on analysis of RI strains should be interpreted with caution. To facilitate interpretation of linkage data derived from RI strains, a table is presented giving the 95 percent and 99 percent confidence intervals for all possible linkages detected with up to 45 RI strains.
Similar articles
- Three-locus linkage analysis using recombinant inbred strains and Bayes' theorem.
Neumann PE. Neumann PE. Genetics. 1991 Jul;128(3):631-8. doi: 10.1093/genetics/128.3.631. Genetics. 1991. PMID: 1874419 Free PMC article. - Two-locus linkage analysis using recombinant inbred strains and Bayes' theorem.
Neumann PE. Neumann PE. Genetics. 1990 Sep;126(1):277-84. doi: 10.1093/genetics/126.1.277. Genetics. 1990. PMID: 2227386 Free PMC article. - Statistical considerations for linkage analysis using recombinant inbred strains and backcrosses.
Silver J, Buckler CE. Silver J, et al. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1423-7. doi: 10.1073/pnas.83.5.1423. Proc Natl Acad Sci U S A. 1986. PMID: 3456595 Free PMC article. - Inference in linkage analysis of multifactorial traits using recombinant inbred strains of mice.
Neumann PE. Neumann PE. Behav Genet. 1992 Nov;22(6):665-76. doi: 10.1007/BF01066637. Behav Genet. 1992. PMID: 1290452 Review. - Quantitative trait locus (QTL) mapping in aging systems.
Hsu HC, Lu L, Yi N, Van Zant G, Williams RW, Mountz JD. Hsu HC, et al. Methods Mol Biol. 2007;371:321-48. doi: 10.1007/978-1-59745-361-5_23. Methods Mol Biol. 2007. PMID: 17634591 Review.
Cited by
- Linkage mapping of a mouse gene, iv, that controls left-right asymmetry of the heart and viscera.
Brueckner M, D'Eustachio P, Horwich AL. Brueckner M, et al. Proc Natl Acad Sci U S A. 1989 Jul;86(13):5035-8. doi: 10.1073/pnas.86.13.5035. Proc Natl Acad Sci U S A. 1989. PMID: 2740340 Free PMC article. - Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection.
Patarca R, Freeman GJ, Singh RP, Wei FY, Durfee T, Blattner F, Regnier DC, Kozak CA, Mock BA, Morse HC 3rd, Jerrells TR, Cantor H. Patarca R, et al. J Exp Med. 1989 Jul 1;170(1):145-61. doi: 10.1084/jem.170.1.145. J Exp Med. 1989. PMID: 2787378 Free PMC article. - RI Manager, a microcomputer program for analysis of data from recombinant inbred strains.
Manly KF, Elliott RW. Manly KF, et al. Mamm Genome. 1991;1(2):123-6. doi: 10.1007/BF02443789. Mamm Genome. 1991. PMID: 1799788 - Chromosomal localization of the murine stress protein gene encoding glucose-regulated protein 78 (BiP).
Gaskins HR, Prochazka M, Leiter EH. Gaskins HR, et al. Mamm Genome. 1992;3(12):709-11. doi: 10.1007/BF00444367. Mamm Genome. 1992. PMID: 1362103 No abstract available. - A preferred region for integration of Friend murine leukemia virus in hematopoietic neoplasms is closely linked to the Int-2 oncogene.
Silver J, Buckler CE. Silver J, et al. J Virol. 1986 Dec;60(3):1156-8. doi: 10.1128/JVI.60.3.1156-1158.1986. J Virol. 1986. PMID: 2878090 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources