Immunogenicity of amyloid - PubMed (original) (raw)

• PMID: 4104285
• PMCID: PMC1455945

Immunogenicity of amyloid

E S Cathcart et al. Immunology. 1971 Jun.

Abstract

Human amyloid appears to contain two immunogenic components, the P (plasma) component and the F (fibril) component. Antisera to P component react with both autologous and homologous antigens by immunodiffusion and fluorescent antibody techniques; antisera to F component react with autologous antigens by immunodiffusion and fluorescent antibody techniques, but react with homologous antigens only by the fluorescent antibody method. Antisera to both P component and F component fail to react with non-amyloid human tissues as well as amyloid deposits in guinea-pig tissues. These results point to heterogeneity in the antigenic determinants of human amyloid and possibly greater inter-species heterogeneity of amyloid.

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