Immune reactions in mucous membranes. IV. Histochemistry of intestinal mast cells during helminth expulsion in the rat - PubMed (original) (raw)

. 1972 Oct;69(1):195-208.

PMID: 4117026
PMCID: PMC2032783

Immune reactions in mucous membranes. IV. Histochemistry of intestinal mast cells during helminth expulsion in the rat

H R Miller et al. Am J Pathol. 1972 Oct.

Abstract

The histochemistry of intestinal (IMC) and connective tissue mast cells (CTMC) in the normal rat is compared. Acid mucopolysaccharide appears to be less strongly sulfated and the granule content of monoamines is lower in IMC. After infection with the intestinal helminth, Nippostrongylus brasiliensis, the mucosal content of IMC is altered. During the early phase of immunologic expulsion of this parasite (self-cure) the IMC proliferate and differentiate; the histochemical properties of the granules appear to reflect this process. Very large numbers of mature IMC are found in the mucosa during the later, rapid phase of worm expulsion. Both acid mucopolysaccharide and monoamines are depleted from the granules of these cells; this is consistent with previous studies suggesting that IMC discharge occurs at this stage. These findings lend further support to the hypothesis that the biogenic products of IMC discharge are responsible for the increase in mucosal permeability which occurs during self-cure and which may facilitate the rapid translocation of antiworm antibody into the intestinal lumen.

PubMed Disclaimer

Cited by

Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model.
Yamamoto T, Kodama T, Lee J, Utsunomiya N, Hayashi S, Sakamoto H, Kuramoto H, Kadowaki M. Yamamoto T, et al. PLoS One. 2014 Jan 16;9(1):e85888. doi: 10.1371/journal.pone.0085888. eCollection 2014. PLoS One. 2014. PMID: 24454942 Free PMC article.
Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain.
Carroll SY, O'Mahony SM, Grenham S, Cryan JF, Hyland NP. Carroll SY, et al. PLoS One. 2013 Dec 18;8(12):e84718. doi: 10.1371/journal.pone.0084718. eCollection 2013. PLoS One. 2013. PMID: 24367692 Free PMC article.
Histochemical and ultrastructural modification of mucosal mast cell granules in parasitized mice lacking the beta-chymase, mouse mast cell protease-1.
Wastling JM, Knight P, Ure J, Wright S, Thornton EM, Scudamore CL, Mason J, Smith A, Miller HR. Wastling JM, et al. Am J Pathol. 1998 Aug;153(2):491-504. doi: 10.1016/s0002-9440(10)65592-7. Am J Pathol. 1998. PMID: 9708809 Free PMC article.
Developmental changes in intestinal globule leukocytes of normal rats.
Ikeda Y, Yamashina S. Ikeda Y, et al. Cell Tissue Res. 1993 Sep;273(3):447-55. doi: 10.1007/BF00333699. Cell Tissue Res. 1993. PMID: 8402827
Study of the kinetics of globule leucocytes in the intestinal epithelium of rats after single or double infection with Trichinella spiralis.
Ruitenberg EJ, Elgersma A. Ruitenberg EJ, et al. Br J Exp Pathol. 1980 Jun;61(3):285-90. Br J Exp Pathol. 1980. PMID: 7426383 Free PMC article.

References

1. J Cell Biol. 1965 Jun;25(3):577-92 - PubMed
1. Exp Parasitol. 1965 Oct;17(2):210-7 - PubMed
1. Histochemie. 1965 Oct 1;5(3):221-33 - PubMed
1. Acta Pathol Microbiol Scand. 1966;66(3):303-12 - PubMed
1. Acta Pathol Microbiol Scand. 1966;67(3):365-79 - PubMed

MeSH terms

Substances

LinkOut - more resources

Full Text Sources
- Europe PubMed Central
- PubMed Central

Immune reactions in mucous membranes. IV. Histochemistry of intestinal mast cells during helminth expulsion in the rat - PubMed (original) (raw)