Gene conversion and transfer of genetic information within the inverted region of inversion heterozygotes - PubMed (original) (raw)
Gene conversion and transfer of genetic information within the inverted region of inversion heterozygotes
A Chovnick. Genetics. 1973 Sep.
Abstract
Prior studies of recombination which monitor exchange events in exceedingly short intervals (i.e., separable sites within a cistron) reveal that the basic event in recombination involves a non-reciprocal transfer of information, termed conversion. As a logical consequence of the model suggested by the work in Drosophila, the present investigation examined recombination between rosy mutant alleles (ry:3-52.0) in Drosophila melanogaster in a paracentric inversion (In(3R)P(18)) heterozygote, which placed the rosy region approximately at the center of the inverted region. Comparison of the results of this study with experiments carried out in standard chromosome homozygotes reveals a dramatic suppression of classical crossovers between the rosy mutant alleles in the inversion heterozygote. However, conversions continue to occur for all rosy mutant alleles in all heterozygous combinations in the inversion heterozygote. Moreover, the order of magnitude of conversion frequencies seen in the inversion heterozygote does not change from that seen in the standard chromosome homozygote study. The significance of these observations with reference to the role of rearrangements as barriers of information transfer is discussed. Particular attention is directed to the elaborate inversion polymorphisms seen in natural populations, and to notions concerning their role in the evolution of adaptive gene complexes.
Similar articles
- Recombination can initiate and terminate at a large number of sites within the rosy locus of Drosophila melanogaster.
Clark SH, Hilliker AJ, Chovnick A. Clark SH, et al. Genetics. 1988 Feb;118(2):261-6. doi: 10.1093/genetics/118.2.261. Genetics. 1988. PMID: 2834266 Free PMC article. - Studies on gene conversion and its relationship to linked exchange in Drosophila melanogaster.
Chovnick A, Ballantyne GH, Holm DG. Chovnick A, et al. Genetics. 1971 Oct;69(2):179-209. doi: 10.1093/genetics/69.2.179. Genetics. 1971. PMID: 5002749 Free PMC article. No abstract available. - The effect of DNA sequence polymorphisms on intragenic recombination in the rosy locus of Drosophila melanogaster.
Hilliker AJ, Clark SH, Chovnick A. Hilliker AJ, et al. Genetics. 1991 Nov;129(3):779-81. doi: 10.1093/genetics/129.3.779. Genetics. 1991. PMID: 1752421 Free PMC article. - Organization of the Rosy locus in Drosophila melanogaster.
Chovnick A, Gelbart W, McCarron M. Chovnick A, et al. Cell. 1977 May;11(1):1-10. doi: 10.1016/0092-8674(77)90312-9. Cell. 1977. PMID: 406047 Review. No abstract available. - Mapping of behavior in Drosophila mosaics.
Hotta Y, Benzer S. Hotta Y, et al. Symp Soc Dev Biol. 1973;31:129-67. doi: 10.1016/b978-0-12-612975-5.50010-x. Symp Soc Dev Biol. 1973. PMID: 4205816 Review. No abstract available.
Cited by
- The fitness consequences of genetic divergence between polymorphic gene arrangements.
Charlesworth B. Charlesworth B. Genetics. 2024 Mar 6;226(3):iyad218. doi: 10.1093/genetics/iyad218. Genetics. 2024. PMID: 38147527 Free PMC article. - The effects of inversion polymorphisms on patterns of neutral genetic diversity.
Charlesworth B. Charlesworth B. Genetics. 2023 Aug 9;224(4):iyad116. doi: 10.1093/genetics/iyad116. Genetics. 2023. PMID: 37348059 Free PMC article. - Heterozygous inversion breakpoints suppress meiotic crossovers by altering recombination repair outcomes.
Li H, Berent E, Hadjipanteli S, Galey M, Muhammad-Lahbabi N, Miller DE, Crown KN. Li H, et al. PLoS Genet. 2023 Apr 13;19(4):e1010702. doi: 10.1371/journal.pgen.1010702. eCollection 2023 Apr. PLoS Genet. 2023. PMID: 37053290 Free PMC article. - Supergene origin and maintenance in Atlantic cod.
Matschiner M, Barth JMI, Tørresen OK, Star B, Baalsrud HT, Brieuc MSO, Pampoulie C, Bradbury I, Jakobsen KS, Jentoft S. Matschiner M, et al. Nat Ecol Evol. 2022 Apr;6(4):469-481. doi: 10.1038/s41559-022-01661-x. Epub 2022 Feb 17. Nat Ecol Evol. 2022. PMID: 35177802 Free PMC article. - Extensive Recombination Suppression and Epistatic Selection Causes Chromosome-Wide Differentiation of a Selfish Sex Chromosome in Drosophila pseudoobscura.
Fuller ZL, Koury SA, Leonard CJ, Young RE, Ikegami K, Westlake J, Richards S, Schaeffer SW, Phadnis N. Fuller ZL, et al. Genetics. 2020 Sep;216(1):205-226. doi: 10.1534/genetics.120.303460. Epub 2020 Jul 30. Genetics. 2020. PMID: 32732371 Free PMC article.
References
- Genetics. 1965 Nov;52(5):977-81 - PubMed
- Proc Natl Acad Sci U S A. 1970 Apr;65(4):939-46 - PubMed
- Nature. 1970 Oct 31;228(5270):442-4 - PubMed
- Genetics. 1970 Oct;66(2):315-29 - PubMed
- Genetics. 1971 Oct;69(2):179-209 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials