Correlation of in vitro growth properties and tumorigenicity of Syrian hamster cell lines - PubMed (original) (raw)
Comparative Study
. 1979 May;39(5):1504-10.
- PMID: 427793
Comparative Study
Correlation of in vitro growth properties and tumorigenicity of Syrian hamster cell lines
J C Barrett et al. Cancer Res. 1979 May.
Abstract
Several in vitro phenotypic characteristics frequently associated with neoplastic cells were examined in a series of spontaneous and benzo(a)pyrene-induced Syrian hamster clonal cell lines which differed in their degree of tumorigenicity. Nonparametric statistical analysis demonstrated cloning efficiency in semisolid agar, enhanced fibrinolytic activity, decreased serum requirement for growth, decreased organization of intracellular actin, and increased cloning efficiency in liquid medium to be correlated with tumorigenicity. These correlations were not only qualitative but also quantitative. This suggests that the factors determining the degree of tumorigenicity of a cell can be cellular growth properties.