Effects of glucose on glycogen synthetase, phosphorylase, and glycogen deposition in the perfused rat liver - PubMed (original) (raw)

Effects of glucose on glycogen synthetase, phosphorylase, and glycogen deposition in the perfused rat liver

H Buschiazzo et al. Proc Natl Acad Sci U S A. 1970 Feb.

Abstract

An increase in the perfusate glucose concentration from near zero to about 11 mM increased glycogen synthesis in the perfused, isolated rat liver from zero to a value about half the maximum seen in the intact animal. Increased synthesis appeard to due not only to provision of substrate but also to conversion of glycogen synthetase to the active form and of glycogen phosphorylase to the inactive form. These glucose effects, which are apparently independent of changes in levels of hormones or adenosine 3':5'-cyclic phosphate, may be physiologically significant for control of the blood glucose level.

PubMed Disclaimer

Similar articles

• Inactivation of rat liver glycogen synthetase by 3':5'-cyclic nucleotides.
  Glinsmann WH, Hern EP. Glinsmann WH, et al. Biochem Biophys Res Commun. 1969 Sep 10;36(6):931-6. doi: 10.1016/0006-291x(69)90293-9. Biochem Biophys Res Commun. 1969. PMID: 4310149 No abstract available.
• Hormonal regulation of glycogen metabolism in neonatal rat liver.
  Schwartz AL, Rall TW. Schwartz AL, et al. Biochem J. 1973 Aug;134(4):985-93. doi: 10.1042/bj1340985. Biochem J. 1973. PMID: 4357717 Free PMC article.
• Mode of thyroxine action in the activation of glycogen synthetase of Rana catesbeiana tadpoles.
  Blatt LM, Kim KH. Blatt LM, et al. Biochim Biophys Acta. 1969 Nov 18;192(2):286-91. doi: 10.1016/0304-4165(69)90367-5. Biochim Biophys Acta. 1969. PMID: 4313073 No abstract available.
• Mechanism of control of hepatic glycogenesis by insulin.
  Miller TB Jr, Larner J. Miller TB Jr, et al. J Biol Chem. 1973 May 25;248(10):3483-8. J Biol Chem. 1973. PMID: 4349866 No abstract available.
• The control of glycogen synthesis in the liver.
  Hers HG, De Wulf H, Stalmans W, van den Berghe G. Hers HG, et al. Adv Enzyme Regul. 1970;8:171-90. doi: 10.1016/0065-2571(70)90016-6. Adv Enzyme Regul. 1970. PMID: 4320023 Review. No abstract available.

Cited by

• Glycogen synthesis in the perfused liver of streptozotocin-diabetic rats.
  Whitton PD, Hems DA. Whitton PD, et al. Biochem J. 1975 Aug;150(2):153-65. doi: 10.1042/bj1500153. Biochem J. 1975. PMID: 126685 Free PMC article.
• Reduced sensitivity of the hepatic adenylate cyclase-cyclic AMP system to glucagon during sustained hormonal stimulation.
  DeRubertis FR, Craven P. DeRubertis FR, et al. J Clin Invest. 1976 Feb;57(2):435-43. doi: 10.1172/JCI108294. J Clin Invest. 1976. PMID: 176180 Free PMC article.
• Glucose metabolism in the newborn rat. Hormonal effects in vivo.
  Snell K, Walker DG. Snell K, et al. Biochem J. 1973 Aug;134(4):899-906. doi: 10.1042/bj1340899. Biochem J. 1973. PMID: 4357715 Free PMC article.
• Glycogen metabolism in human hormone-producing trophoblastic cells in continuous culture. I. Regulation of glycogen metabolism by glucose.
  Pattillo RA, Hussa RO, Garancis JC. Pattillo RA, et al. In Vitro. 1971 Sep-Oct;7(2):59-67. doi: 10.1007/BF02628263. In Vitro. 1971. PMID: 5170777 No abstract available.

References

1. 1. J Biol Chem. 1965 Nov;240(11):4515-23 - PubMed
2. 1. Am J Med. 1966 May;40(5):709-15 - PubMed
3. 1. J Biol Chem. 1966 Sep 10;241(17):3873-81 - PubMed
4. 1. Biochim Biophys Acta. 1966 Jun 29;121(2):261-8 - PubMed
5. 1. J Biol Chem. 1967 Jun 10;242(11):2622-36 - PubMed

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central