Synthesis and cleavage of enterovirus polypeptides in mammalian cells - PubMed (original) (raw)
Synthesis and cleavage of enterovirus polypeptides in mammalian cells
E D Kiehn et al. J Virol. 1970 Mar.
Abstract
Evidence is presented that the entire enterovirus ribonucleic acid genome is translated into a single giant polypeptide of well over 200,000 daltons molecular weight. This giant protein was detected repeatedly in coxsackievirus B1-infected cells, even in the absence of amino acid analogues. The enzymes which cleave this giant protein into smaller structural and enzymatic proteins accumulate with increasing time after infection. It appears that they are either virus-coded proteolytic enzymes or else host enzymes which are activated or released from an intracellular site as a result of virus infection. These cleavage enzymes do not cause grossly apparent cleavage of host-cell proteins.
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References
- Proc Natl Acad Sci U S A. 1965 Aug;54(2):505-13 - PubMed
- Science. 1966 Feb 25;151(3713):988-90 - PubMed
- Virology. 1967 Sep;33(1):36-46 - PubMed
- Biochem Biophys Res Commun. 1967 Sep 7;28(5):815-20 - PubMed
- Proc Natl Acad Sci U S A. 1968 Mar;59(3):966-71 - PubMed
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