Myelin deficiency (md): a neurologic mutant in the Wistar rat - PubMed (original) (raw)

• PMID: 434110
• PMCID: PMC2042295

Myelin deficiency (md): a neurologic mutant in the Wistar rat

C K Csiza et al. Am J Pathol. 1979 Apr.

Abstract

Myelin deficiency (md), a newly discovered neurologic mutation in the Wistar rat, is transmitted by an X-linked, recessive lethal gene. Male rats are affected, and the first symptom is a head tremor recognizable at 12 to 15 days of age. The tremors become generalized within a few days and disappear when the animal is at rest. In the later stages, from 17 to 21 days of age, the slightest disturbance will precipitate a generalized seizure. Pups die within 30 days after birth. The only gross postmortem change is a gray color of the spinal cord instead of its normally white appearance. Microscopic findings reveal total lack of myelin formation at all levels of the central nervous system.

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