The nucleotide sequence complexity of avian tumor virus RNA - PubMed (original) (raw)
The nucleotide sequence complexity of avian tumor virus RNA
M A Billeter et al. Proc Natl Acad Sci U S A. 1974 Sep.
Abstract
The nucleotide sequence complexity of 60-70S RNA of Rous sarcoma virus was determined from the molar yields of 11 pure oligonucleotides of known chain length, obtained from [(32)P]RNA of Rous sarcoma virus by T1 RNase digestion and two-dimensional polyacrylamide gel electrophoresis. We calculate an apparent chain length of about 9800 nucleotides, corresponding to a molecular weight of 3.4 x 10(6). Assuming the molecular weight of 60-70S RNA of Rous sarcoma virus to be about 10(7), our data suggest that the virus genome consists of identical, or very similar, nucleotide sequences repeated three to four times.
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