Two types of amino acid substitutions in protein evolution - PubMed (original) (raw)

Comparative Study

. 1979 Mar 15;12(3):219-36.

doi: 10.1007/BF01732340.

• PMID: 439147
• DOI: 10.1007/BF01732340

Comparative Study

Two types of amino acid substitutions in protein evolution

T Miyata et al. J Mol Evol. 1979.

Abstract

The frequency of amino acid substitutions, relative to the frequency expected by chance, decreases linearly with the increase in physico-chemical differences between amino acid pairs involved in a substitution. This correlation does not apply to abnormal human hemoglobins. Since abnormal hemoglobins mostly reflect the process of mutation rather than selection, the correlation manifest during protein evolution between substitution frequency and physico-chemical difference in amino acids can be attributed to natural selection. Outside of 'abnormal' proteins, the correlation also does not apply to certain regions of proteins characterized by rapid rates of substitution. In these cases again, except for the largest physico-chemical differences between amino acid pairs, the substitution frequencies seem to be independent of the physico-chemical parameters. The limination of the substituents involving the largest physico-chemical differences can once more be attributed to natural selection. For smaller physico-chemical differences, natural selection, if it is operating in the polypeptide regions, must be based on parameters other than those examined.

PubMed Disclaimer

Similar articles

• Detection of conserved physico-chemical characteristics of proteins by analyzing clusters of positions with co-ordinated substitutions.
  Afonnikov DA, Oshchepkov DY, Kolchanov NA. Afonnikov DA, et al. Bioinformatics. 2001 Nov;17(11):1035-46. doi: 10.1093/bioinformatics/17.11.1035. Bioinformatics. 2001. PMID: 11724732
• Conservation of physico-chemical amino acid properties during the evolution of proteins.
  Soto MA, Tohá J. Soto MA, et al. Orig Life. 1983 Dec;13(2):147-52. doi: 10.1007/BF00928892. Orig Life. 1983. PMID: 6669375
• Amino acid preferences of small proteins. Implications for protein stability and evolution.
  White SH. White SH. J Mol Biol. 1992 Oct 20;227(4):991-5. doi: 10.1016/0022-2836(92)90515-l. J Mol Biol. 1992. PMID: 1433304 Review.
• Correlated substitution analysis and the prediction of amino acid structural contacts.
  Horner DS, Pirovano W, Pesole G. Horner DS, et al. Brief Bioinform. 2008 Jan;9(1):46-56. doi: 10.1093/bib/bbm052. Epub 2007 Nov 13. Brief Bioinform. 2008. PMID: 18000015 Review.

Cited by

• Fitness conferred by replaced amino acids declines with time.
  Naumenko SA, Kondrashov AS, Bazykin GA. Naumenko SA, et al. Biol Lett. 2012 Oct 23;8(5):825-8. doi: 10.1098/rsbl.2012.0356. Epub 2012 May 23. Biol Lett. 2012. PMID: 22628094 Free PMC article.
• COVID-19 in a Pre-Omicron Era: A Cross-Sectional Immuno-Epidemical and Genomic Evaluation.
  Pagnossa JP, Rodrigues SO, Oliveira GF, Adnan M, Aljaid MS, Assis IB, Lima ASG, Patel M, Ogaly HA, Batiha GE. Pagnossa JP, et al. Vaccines (Basel). 2023 Jan 27;11(2):272. doi: 10.3390/vaccines11020272. Vaccines (Basel). 2023. PMID: 36851150 Free PMC article.
• Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.
  Chanock SJ, Burdett L, Yeager M, Llaca V, Langerød A, Presswalla S, Kaaresen R, Strausberg RL, Gerhard DS, Kristensen V, Perou CM, Børresen-Dale AL. Chanock SJ, et al. Breast Cancer Res. 2007;9(1):R5. doi: 10.1186/bcr1637. Breast Cancer Res. 2007. PMID: 17224074 Free PMC article.
• Compensated pathogenic variants in coagulation factors VIII and IX present complex mapping between molecular impact and hemophilia severity.
  Marín Ò, Aguirre J, de la Cruz X. Marín Ò, et al. Sci Rep. 2019 Jul 2;9(1):9538. doi: 10.1038/s41598-019-45916-3. Sci Rep. 2019. PMID: 31267011 Free PMC article.
• Extraordinary divergence and positive Darwinian selection in a fusagenic protein coating the acrosomal process of abalone spermatozoa.
  Swanson WJ, Vacquier VD. Swanson WJ, et al. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4957-61. doi: 10.1073/pnas.92.11.4957. Proc Natl Acad Sci U S A. 1995. PMID: 7761431 Free PMC article.

References

1. 1. J Mol Evol. 1977 Apr 29;9(2):159-80 - PubMed
2. 1. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2848-52 - PubMed
3. 1. Prog Biophys Mol Biol. 1976;31(1):67-93 - PubMed
4. 1. Proc Natl Acad Sci U S A. 1975 Mar;72(3):819-23 - PubMed
5. 1. Br Med J. 1954 Feb 6;1(4857):290-4 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Other Literature Sources

  • The Lens - Patent Citations Database