Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse - PubMed (original) (raw)
Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse
F H Bach et al. J Exp Med. 1972.
Abstract
The mixed leukocyte culture (MLC) test is an in vitro model of the recognition phase of the homograft response. For the most part, activation in MLC is dependent on differences of the major histocompatibility complex (MHC). Our present studies in the mouse suggest that activation is primarily associated with differences of genetic regions of the MHC other than those which control the serologically defined (H-2) antigens. These differences do not lead to cytotoxic or agglutinating antibody formation despite extensive immunization; we have called these differences lymphocyte-defined (LD) differences. The strongest stimulation in MLC is associated with differences of the Ir region. It is possible that the Ir product is the T cell receptor and that it is this same molecule which can act as the stimulatory agent in MLC. Other possibilities are discussed.
Similar articles
- B-cell alloantigens determined by the H-2 linked Ir region are associated with mixed lymphocyte culture stimulation.
Lozner EC, Sachs DH, Shearer GM, Terry WD. Lozner EC, et al. Science. 1974 Feb 22;183(4126):757-9. doi: 10.1126/science.183.4126.757. Science. 1974. PMID: 4150717 - Genetic control of major complex histocompatibility antigens.
Bcah FH. Bcah FH. Genetics. 1975 Jun;79 Suppl:263-75. Genetics. 1975. PMID: 125215 - Genetics of transplantation: the major histocompatibility complex.
Bach FH. Bach FH. Annu Rev Genet. 1976;10:319-39. doi: 10.1146/annurev.ge.10.120176.001535. Annu Rev Genet. 1976. PMID: 138383 - Differential cellular immune responsiveness to systems of the major histocompatibility complex.
Bach FH. Bach FH. J Allergy Clin Immunol. 1976 Feb;57(2):95-111. doi: 10.1016/0091-6749(76)90029-4. J Allergy Clin Immunol. 1976. PMID: 55429 Review. - The major histocompatibility complex and its relationship to allergic disease.
Bach FH. Bach FH. Ann Allergy. 1976 Nov;37(5):307-27. Ann Allergy. 1976. PMID: 136913 Review.
Cited by
- The early history of Stanford Immunology.
Jones PP, Herzenberg LA. Jones PP, et al. Immunol Res. 2014 May;58(2-3):164-78. doi: 10.1007/s12026-014-8518-z. Immunol Res. 2014. PMID: 24804901 Review. - A methods paper that led to much more.
Roopenian D. Roopenian D. J Immunol. 2014 Jan 1;192(1):3-4. doi: 10.4049/jimmunol.1303010. J Immunol. 2014. PMID: 24363430 Free PMC article. No abstract available. - Multigenic natural variation underlies Caenorhabditis elegans olfactory preference for the bacterial pathogen Serratia marcescens.
Glater EE, Rockman MV, Bargmann CI. Glater EE, et al. G3 (Bethesda). 2014 Feb 19;4(2):265-76. doi: 10.1534/g3.113.008649. G3 (Bethesda). 2014. PMID: 24347628 Free PMC article. - Multi-Locus control of MLC reactions in rhesus monkeys.
Widmer MB, Balner H. Widmer MB, et al. Immunogenetics. 1978 Dec;7(1):155-64. doi: 10.1007/BF01844001. Immunogenetics. 1978. PMID: 21302069 - Cellular and humoral immune responses after fresh meniscal allografts in mice. A preliminary report.
Ochi M, Ikuta Y, Ishida O, Akiyama M. Ochi M, et al. Arch Orthop Trauma Surg. 1993;112(4):163-6. doi: 10.1007/BF00662281. Arch Orthop Trauma Surg. 1993. PMID: 8357690
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials