Erythropoietin production in cultures of goat renal glomeruli - PubMed (original) (raw)

Erythropoietin production in cultures of goat renal glomeruli

H Burlington et al. Proc Natl Acad Sci U S A. 1972 Dec.

Abstract

Cultures initiated with isolated goat-kidney glomeruli produce erythropoietin over periods of 7 months. Production seems dependent upon a minimum interval of about 30 days between changes of medium. Experiments distinguishing between erythropoietin, renal activator, and serum substrate support the conclusion that the factor released to the medium of long-term glomerular cultures is erythropoietin itself. The system offers promising opportunities for studying regulation of erythropoietin production, and possibly could be developed as a source of significant quantities of the hormone.

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References

1. 1. Ann N Y Acad Sci. 1968 Mar 29;149(1):40-5 - PubMed
2. 1. Fed Proc. 1969 May-Jun;28(3):1234-7 - PubMed
3. 1. Life Sci. 1969 Sep 15;8(18):949-54 - PubMed
4. 1. J Lab Clin Med. 1971 May;77(5):751-8 - PubMed
5. 1. Blood. 1972 Aug;40(2):189-97 - PubMed

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