Self-association of cholesterol in aqueous solution - PubMed (original) (raw)

Self-association of cholesterol in aqueous solution

M E Haberland et al. Proc Natl Acad Sci U S A. 1973 Aug.

Abstract

Cholesterol has a maximum solubility in aqueous solutions of 1.8 mug/ml or 4.7 muM. It undergoes a thermodynamically reversible self-association with a critical micelle concentration of 25 to 40 nM at 25 degrees . The cholesterol micelle is heterogeneous in size, probably rodlike in shape, and stabilized by an unusually high interaction energy between the aggregated monomers.

PubMed Disclaimer

Similar articles

• Cholesterol in aqueous solution: hydrophobicity and self-association.
  Gilbert DB, Tanford C, Reynolds JA. Gilbert DB, et al. Biochemistry. 1975 Jan 28;14(2):444-8. doi: 10.1021/bi00673a035. Biochemistry. 1975. PMID: 1120112
• An interaction between oestradiol and progesterone in aqueous solutions and in a model membrane system.
  Heap RB, Symons AM, Watkins JC. Heap RB, et al. Biochim Biophys Acta. 1971 Apr 13;233(2):307-14. doi: 10.1016/0005-2736(71)90328-2. Biochim Biophys Acta. 1971. PMID: 5105272 No abstract available.
• Density gradient proportionality constants for a number of aqueous binary solutions.
  Ifft JB, Martin WR 3rd, Kinzie K. Ifft JB, et al. Biopolymers. 1970;9(5):597-614. doi: 10.1002/bip.1970.360090505. Biopolymers. 1970. PMID: 5437367 No abstract available.
• Micelle formation by bile salts. Physical-chemical and thermodynamic considerations.
  Carey MC, Small DM. Carey MC, et al. Arch Intern Med. 1972 Oct;130(4):506-27. Arch Intern Med. 1972. PMID: 4562149 Review. No abstract available.
• Proteoglycans: an overview.
  Kuettner KE, Kimura JH. Kuettner KE, et al. J Cell Biochem. 1985;27(4):327-36. doi: 10.1002/jcb.240270403. J Cell Biochem. 1985. PMID: 3922997 Review. No abstract available.

Cited by

• Carbosilane Dendritic Amphiphiles from Cholesterol or Vitamin E for Micelle Formation.
  Mencia G, Algar S, Lozano-Cruz T, Muñoz-Fernández MÁ, Gillies ER, Cano J, Valiente M, Gómez R. Mencia G, et al. Pharmaceutics. 2024 Mar 25;16(4):451. doi: 10.3390/pharmaceutics16040451. Pharmaceutics. 2024. PMID: 38675112 Free PMC article.
• The pathophysiology of excess plasma-free cholesterol.
  Gillard BK, Rosales C, Gotto AM Jr, Pownall HJ. Gillard BK, et al. Curr Opin Lipidol. 2023 Dec 1;34(6):278-286. doi: 10.1097/MOL.0000000000000899. Epub 2023 Sep 25. Curr Opin Lipidol. 2023. PMID: 37732779 Free PMC article. Review.
• Lipid oxidation controls peptide self-assembly near membranes through a surface attraction mechanism.
  John T, Piantavigna S, Dealey TJA, Abel B, Risselada HJ, Martin LL. John T, et al. Chem Sci. 2023 Mar 2;14(14):3730-3741. doi: 10.1039/d3sc00159h. eCollection 2023 Apr 5. Chem Sci. 2023. PMID: 37035708 Free PMC article.
• The Inseparable Relationship Between Cholesterol and Hedgehog Signaling.
  Siebold C, Rohatgi R. Siebold C, et al. Annu Rev Biochem. 2023 Jun 20;92:273-298. doi: 10.1146/annurev-biochem-052521-040313. Epub 2023 Mar 31. Annu Rev Biochem. 2023. PMID: 37001135 Free PMC article. Review.
• Effect of Coffee on the Bioavailability of Sterols.
  Pires CL, Silva IMV, Coimbra MA, Moreno MJ, Coreta-Gomes F. Pires CL, et al. Foods. 2022 Sep 20;11(19):2935. doi: 10.3390/foods11192935. Foods. 2022. PMID: 36230011 Free PMC article.

References

1. 1. J Biol Chem. 1961 May;236:1372-9 - PubMed
2. 1. J Mol Biol. 1972 Jun 14;67(1):59-74 - PubMed
3. 1. Proc Natl Acad Sci U S A. 1970 Jul;66(3):1002-7 - PubMed
4. 1. J Biol Chem. 1967 Mar 25;242(6):1205-10 - PubMed
5. 1. Proc Natl Acad Sci U S A. 1957 Jul 15;43(7):581-8 - PubMed

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations