Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells - PubMed (original) (raw)
Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells
N Jones et al. Cell. 1979 Jul.
Abstract
A series of adenovirus type 5 (Ad5) deletion, insertion and substitution mutants, some of which are defective for transformation of rat cells, have been isolated. The mutants were selected as variants which lack the Xba I endonuclease cleavage site at 4 map units on the viral chromosome. The deletions range in size from 150-2300 bp and are located between 1.5 and 10.5 map units. The mutants can be propagated in 293 cells (Ad5-transformed human embryonic kidney cells), but are defective for growth in HeLa or human embryonic kidney cells. No viral DNA synthesis was observed in mutant virus-infected HeLa cells. All but one of the deletion mutants tested were defective for transformation of rat embryo and rat embryo brain cells.
Similar articles
- Mutations in the E1a gene of type 5 adenovirus result in oncogenic transformation of Fischer rat embryo cells.
Duigou GJ, Babiss LE, Liaw WS, Zimmer SG, Ginsberg HS, Fisher PB. Duigou GJ, et al. J Cell Biochem. 1987 Feb;33(2):117-26. doi: 10.1002/jcb.240330206. J Cell Biochem. 1987. PMID: 3571338 - Separation of the functions controlled by adenovirus 2 lp+ locus.
Subramanian T, Chinnadurai G. Subramanian T, et al. Virology. 1986 Apr 30;150(2):381-9. doi: 10.1016/0042-6822(86)90303-x. Virology. 1986. PMID: 3962186 - Complementation of adenovirus type 5 host range mutants by adenovirus type 12 in coinfected HeLa and BHK-21 cells.
Rowe DT, Graham FL. Rowe DT, et al. J Virol. 1981 Apr;38(1):191-7. doi: 10.1128/JVI.38.1.191-197.1981. J Virol. 1981. PMID: 7241651 Free PMC article. - Cooperation between multiple oncogenes in rodent embryo fibroblasts: an experimental model of tumor progression?
Glaichenhaus N, Mougneau E, Connan G, Rassoulzadegan M, Cuzin F. Glaichenhaus N, et al. Adv Cancer Res. 1985;45:291-305. doi: 10.1016/s0065-230x(08)60271-7. Adv Cancer Res. 1985. PMID: 3004122 Review. No abstract available.
Cited by
- Adenovirus E1A binding to DCAF10 targets proteasomal degradation of RUVBL1/2 AAA+ ATPases required for quaternary assembly of multiprotein machines, innate immunity, and responses to metabolic stress.
Zemke NR, Hsu E, Barshop WD, Sha J, Wohlschlegel JA, Berk AJ. Zemke NR, et al. J Virol. 2023 Dec 21;97(12):e0099323. doi: 10.1128/jvi.00993-23. Epub 2023 Nov 14. J Virol. 2023. PMID: 37962355 Free PMC article. - The use of adenoviral vectors in gene therapy and vaccine approaches.
Araújo NM, Rubio IGS, Toneto NPA, Morale MG, Tamura RE. Araújo NM, et al. Genet Mol Biol. 2022 Oct 7;45(3 Suppl 1):e20220079. doi: 10.1590/1678-4685-GMB-2022-0079. eCollection 2022. Genet Mol Biol. 2022. PMID: 36206378 Free PMC article. - Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus.
Koch J, Schober SJ, Hindupur SV, Schöning C, Klein FG, Mantwill K, Ehrenfeld M, Schillinger U, Hohnecker T, Qi P, Steiger K, Aichler M, Gschwend JE, Nawroth R, Holm PS. Koch J, et al. Nat Commun. 2022 Aug 10;13(1):4689. doi: 10.1038/s41467-022-32087-5. Nat Commun. 2022. PMID: 35948546 Free PMC article. - Evidence That the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments.
Hidalgo P, Pimentel A, Mojica-Santamaría D, von Stromberg K, Hofmann-Sieber H, Lona-Arrona C, Dobner T, González RA. Hidalgo P, et al. Viruses. 2021 Sep 6;13(9):1778. doi: 10.3390/v13091778. Viruses. 2021. PMID: 34578359 Free PMC article. - A potential bat adenovirus-based oncolytic virus targeting canine cancers.
Matsugo H, Kitamura-Kobayashi T, Kamiki H, Ishida H, Sekine W, Takenaka-Uema A, Nakagawa T, Murakami S, Horimoto T. Matsugo H, et al. Sci Rep. 2021 Aug 18;11(1):16706. doi: 10.1038/s41598-021-96101-4. Sci Rep. 2021. PMID: 34408176 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources