Non-specific and specific active immunotherapy in a B16 murine melanoma system - PubMed (original) (raw)
Non-specific and specific active immunotherapy in a B16 murine melanoma system
J Avent et al. J Surg Oncol. 1979.
Abstract
Conflicts amongst reports concerning the efficacy of both nonspecific and specific attempts at immunotherapy may be ascribed to different animal models utilizing tumors of different immunogenicity. We have selected the B16 mouse melanoma model as the example of a spontaneously occurring neoplasm that is histocompatible with the host and does have tumor-associated antigens. Attempts to alter tumor growth or survival with nonspecific active immunotherapy as well as with specific active immunotherapy were not successful. Nonspecific active pre-immunization failed to alter tumor take or growth. Specific active immunotherapy both with and without adjuvant did decrease tumor take and prolong host survival. The effects were increasingly documented at lower tumor cell inoculums and became less apparent with increase in the tumor cell challenge.
Similar articles
- Inconsistent response of B16 melanoma to BCG immunotherapy.
Kreider JW, Bartlett GL, Purnell DM. Kreider JW, et al. J Natl Cancer Inst. 1976 Apr;56(4):803-10. doi: 10.1093/jnci/56.4.803. J Natl Cancer Inst. 1976. PMID: 1255799 - Immunotherapy of cancer.
Oettgen HF. Oettgen HF. N Engl J Med. 1977 Sep 1;297(9):484-91. doi: 10.1056/NEJM197709012970907. N Engl J Med. 1977. PMID: 301988 No abstract available. - Modulation of antitumor immunity--immunobiologic approaches.
North RJ, Dye ES, Mills CD, Chandler JP. North RJ, et al. Springer Semin Immunopathol. 1982;5(2):193-220. doi: 10.1007/BF00199796. Springer Semin Immunopathol. 1982. PMID: 6293113 Review. No abstract available. - The influence of nonspecific immunotherapy on the course of murine melanoma.
Woods JE, Ritts RE Jr. Woods JE, et al. J Surg Oncol. 1977;9(1):15-20. doi: 10.1002/jso.2930090104. J Surg Oncol. 1977. PMID: 839793 - Active non-specific immunotherapy of experimental tumours.
Silobrcić V. Silobrcić V. Folia Biol (Praha). 1980;26(3):145-66. Folia Biol (Praha). 1980. PMID: 6998756 Review. No abstract available.
Cited by
- Immune evasion by murine melanoma mediated through CC chemokine receptor-10.
Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST. Murakami T, et al. J Exp Med. 2003 Nov 3;198(9):1337-47. doi: 10.1084/jem.20030593. Epub 2003 Oct 27. J Exp Med. 2003. PMID: 14581607 Free PMC article. - Tumor vaccines.
Bystryn JC. Bystryn JC. Cancer Metastasis Rev. 1990 Jul;9(1):81-91. doi: 10.1007/BF00047590. Cancer Metastasis Rev. 1990. PMID: 2208570 Review. - Recombinant BCG therapy suppresses melanoma tumor growth.
Duda RB, Yang H, Dooley DD, Abu-Jawdeh G. Duda RB, et al. Ann Surg Oncol. 1995 Nov;2(6):542-9. doi: 10.1007/BF02307089. Ann Surg Oncol. 1995. PMID: 8591086
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources