Inhibition of influenza virus uncoating by rimantadine hydrochloride - PubMed (original) (raw)

Inhibition of influenza virus uncoating by rimantadine hydrochloride

W C Koff et al. J Virol. 1979 Jul.

Abstract

In freeze-thaw lysates of MDCK cells infected with 32P-labeled influenza virus A/WSN in the presence of added RNase, acid-precipitable radioactivity diminished to about 50% of initial values within 90 min after a 1-h virus adsorption period. A similar preparation containing rimantadine at a concentration of 50 micrograms/ml exhibited only a 10% reduction in acid-precipitable radioactivity. These findings suggest that rimantadine interferes with uncoating of influenza virus in infected cells.

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