Psychotomimetic N-methylated tryptamines: formation in brain in vivo and in vitro - PubMed (original) (raw)

Psychotomimetic N-methylated tryptamines: formation in brain in vivo and in vitro

J M Saavedra et al. Science. 1972.

Abstract

The use of a sensitive enzymatic assay demonstrates that tryptamine occurs normally in rat brain. Intracisternal administration of [(14)C]tryptamine results in the formation of N-methyl-and dimethyltryptamine(a psychotomimetic compound)in the rat brain. An enzyme that converts tryptamine and N-methyl-tryptamine to N-methyl-and dimethyltryptamine was found to be present in rat and human brain. The N-methylation of tryptamine was inhibited by normally occurring compounds present in rat brain.

PubMed Disclaimer

Similar articles

• Distribution and metabolism of tryptamine in rat brain.
  Wu PH, Boulton AA. Wu PH, et al. Can J Biochem. 1973 Jul;51(7):1104-12. doi: 10.1139/o73-144. Can J Biochem. 1973. PMID: 4725358 No abstract available.
• Indolethylamine N-methyltransferase (INMT) is not essential for endogenous tryptamine-dependent methylation activity in rats.
  Glynos NG, Carter L, Lee SJ, Kim Y, Kennedy RT, Mashour GA, Wang MM, Borjigin J. Glynos NG, et al. Sci Rep. 2023 Jan 6;13(1):280. doi: 10.1038/s41598-023-27538-y. Sci Rep. 2023. PMID: 36609666 Free PMC article.
• [Effect of monoamine oxidase inhibitors on the tryptamine content of the rat brain and on "tryptamine convulsions"].
  Popov N, Lietz W, Matthies H. Popov N, et al. Acta Biol Med Ger. 1967;18(2):233-44. Acta Biol Med Ger. 1967. PMID: 5586804 German. No abstract available.
• Determination and physiological disposition of dimethyltryptamine and diethyltryptamine in rat brain, liver and plasma.
  Cohen I, Vogel WH. Cohen I, et al. Biochem Pharmacol. 1972 Apr 15;21(8):1214-6. doi: 10.1016/0006-2952(72)90119-0. Biochem Pharmacol. 1972. PMID: 5034205 No abstract available.
• [3H]tryptamine autoradiography in rat brain and choroid plexus reveals two distinct sites.
  Perry DC. Perry DC. J Pharmacol Exp Ther. 1986 Feb;236(2):548-59. J Pharmacol Exp Ther. 1986. PMID: 3003349

Cited by

• Multimodal Neuroimaging of the Effect of Serotonergic Psychedelics on the Brain.
  Frautschi PC, Singh AP, Stowe NA, Yu JJ. Frautschi PC, et al. AJNR Am J Neuroradiol. 2024 Feb 15;45(7):833-40. doi: 10.3174/ajnr.A8118. Online ahead of print. AJNR Am J Neuroradiol. 2024. PMID: 38360790 Review.
• Psychedelics: Alternative and Potential Therapeutic Options for Treating Mood and Anxiety Disorders.
  Lowe H, Toyang N, Steele B, Grant J, Ali A, Gordon L, Ngwa W. Lowe H, et al. Molecules. 2022 Apr 14;27(8):2520. doi: 10.3390/molecules27082520. Molecules. 2022. PMID: 35458717 Free PMC article. Review.
• Serotonergic Psychedelics in Neural Plasticity.
  Lukasiewicz K, Baker JJ, Zuo Y, Lu J. Lukasiewicz K, et al. Front Mol Neurosci. 2021 Oct 12;14:748359. doi: 10.3389/fnmol.2021.748359. eCollection 2021. Front Mol Neurosci. 2021. PMID: 34712118 Free PMC article. Review.
• N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo.
  Morales-Garcia JA, Calleja-Conde J, Lopez-Moreno JA, Alonso-Gil S, Sanz-SanCristobal M, Riba J, Perez-Castillo A. Morales-Garcia JA, et al. Transl Psychiatry. 2020 Sep 28;10(1):331. doi: 10.1038/s41398-020-01011-0. Transl Psychiatry. 2020. PMID: 32989216 Free PMC article.
• Toxicological Aspects and Determination of the Main Components of Ayahuasca: A Critical Review.
  Simão AY, Gonçalves J, Duarte AP, Barroso M, Cristóvão AC, Gallardo E. Simão AY, et al. Medicines (Basel). 2019 Oct 18;6(4):106. doi: 10.3390/medicines6040106. Medicines (Basel). 2019. PMID: 31635364 Free PMC article. Review.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon