Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain - PubMed (original) (raw)
Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain
A Goldstein et al. Proc Natl Acad Sci U S A. 1971 Aug.
Abstract
A METHOD IS DESCRIBED FOR ANALYZING THE ASSOCIATION OF THE OPIATE NARCOTIC LEVORPHANOL WITH BRAIN TISSUE INTO THREE COMPONENTS: nonsaturable, saturable nonspecific, and saturable stereospecific. The method may be of general applicability for the study of the interaction of drugs with body tissues. In mouse brain the stereospecific binding of levorphanol represents only 2% of the total association of drug with tissue, and it was found only in certain membrane fractions. The material responsible for the stereospecific binding might be the opiate receptor.
Similar articles
- Partial purification of an opiate receptor from mouse brain.
Lowney LI, Schulz K, Lowery PJ, Goldstein A. Lowney LI, et al. Science. 1974 Feb 22;183(4126):749-53. doi: 10.1126/science.183.4126.749. Science. 1974. PMID: 4821242 - Binding of an opiate, levorphanol, to intact neuroblastoma cells in continuous culture.
North-Root H, Martin DW, Toliver AP. North-Root H, et al. Physiol Chem Phys. 1976;8(3):221-8. Physiol Chem Phys. 1976. PMID: 1013177 - Solubilization of a stereospecific opiate-macromolecular complex from rat brain.
Simon EJ, Hiller JM, Edelman I. Simon EJ, et al. Science. 1975 Oct 24;190(4212):389-90. doi: 10.1126/science.1182043. Science. 1975. PMID: 1182043 - Interactions of narcotic antagonists with receptor sites.
Goldstein A. Goldstein A. Adv Biochem Psychopharmacol. 1973;8(0):471-81. Adv Biochem Psychopharmacol. 1973. PMID: 4212101 Review. No abstract available. - Levorphanol.
[No authors listed] [No authors listed] 2019 Apr 25. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2019 Apr 25. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643300 Free Books & Documents. Review.
Cited by
- Dopamine receptors in human and calf brains, using [3H]apomorphine and an antipsychotic drug.
Seeman P, Chau-Wong M, Tedesco J, Wong K. Seeman P, et al. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4354-8. doi: 10.1073/pnas.73.12.4354. Proc Natl Acad Sci U S A. 1976. PMID: 12505 Free PMC article. - Brain receptors for antipsychotic drugs and dopamine: direct binding assays.
Seeman P, Chau-Wong M, Tedesco J, Wong K. Seeman P, et al. Proc Natl Acad Sci U S A. 1975 Nov;72(11):4376-80. doi: 10.1073/pnas.72.11.4376. Proc Natl Acad Sci U S A. 1975. PMID: 1060115 Free PMC article. - Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands.
Xie GX, Miyajima A, Goldstein A. Xie GX, et al. Proc Natl Acad Sci U S A. 1992 May 1;89(9):4124-8. doi: 10.1073/pnas.89.9.4124. Proc Natl Acad Sci U S A. 1992. PMID: 1315051 Free PMC article. - Opioid activation of toll-like receptor 4 contributes to drug reinforcement.
Hutchinson MR, Northcutt AL, Hiranita T, Wang X, Lewis SS, Thomas J, van Steeg K, Kopajtic TA, Loram LC, Sfregola C, Galer E, Miles NE, Bland ST, Amat J, Rozeske RR, Maslanik T, Chapman TR, Strand KA, Fleshner M, Bachtell RK, Somogyi AA, Yin H, Katz JL, Rice KC, Maier SF, Watkins LR. Hutchinson MR, et al. J Neurosci. 2012 Aug 15;32(33):11187-200. doi: 10.1523/JNEUROSCI.0684-12.2012. J Neurosci. 2012. PMID: 22895704 Free PMC article. - Morphine sulfate stimulates the adenylate cyclase in mouse caudate nuclei.
Tang LC, Cotzias GC. Tang LC, et al. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1546-8. doi: 10.1073/pnas.75.3.1546. Proc Natl Acad Sci U S A. 1978. PMID: 206908 Free PMC article.
References
- J Pharmacol Exp Ther. 1963 Dec;142:291-8 - PubMed
- Biochem J. 1967 Jul;104(1):148-57 - PubMed
- J Pharmacol Exp Ther. 1970 Oct;175(1):84-7 - PubMed
- Nature. 1971 Feb 19;229(5286):554-7 - PubMed
- J Cell Biol. 1966 Aug;30(2):405-15 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials